Abstract
In the past decades, tricyclic acridone ring system has become one of the major research interests of the medicinal chemists due to the biological significance of this moiety in drug design and drug discovery. Acridone scaffold has substantial bio-potential since it possess crucial activities such as antibacterial, antimalarial, antiviral and anti-neoplastic. The diverse biological activity of acridone and its prospective in reversal of multi-drug resistance has attracted attention of medicinal chemists to explore this scaffold especially to treat multi-drug resistance in cancer. Considering this potential in this review we have summarized the synthesis and the antitumor activities of different acridone derived compounds reported from 2000 to 2014.
Keywords: Acridone, antitumor, natural product, synthesis.
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Anti-Cancer Agents in Medicinal Chemistry
Title:Acridone-based Antitumor Agents: A Mini-review
Volume: 15 Issue: 8
Author(s): Wesam S. Alwan, Anand A. Mahajan, Rajesh A. Rane, Anish A. Amritkar, Shital S. Naphade, Mayur C. Yerigiri and Rajshekhar Karpoormath
Affiliation:
Keywords: Acridone, antitumor, natural product, synthesis.
Abstract: In the past decades, tricyclic acridone ring system has become one of the major research interests of the medicinal chemists due to the biological significance of this moiety in drug design and drug discovery. Acridone scaffold has substantial bio-potential since it possess crucial activities such as antibacterial, antimalarial, antiviral and anti-neoplastic. The diverse biological activity of acridone and its prospective in reversal of multi-drug resistance has attracted attention of medicinal chemists to explore this scaffold especially to treat multi-drug resistance in cancer. Considering this potential in this review we have summarized the synthesis and the antitumor activities of different acridone derived compounds reported from 2000 to 2014.
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Cite this article as:
Alwan S. Wesam, Mahajan A. Anand, Rane A. Rajesh, Amritkar A. Anish, Naphade S. Shital, Yerigiri C. Mayur and Karpoormath Rajshekhar, Acridone-based Antitumor Agents: A Mini-review, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (8) . https://dx.doi.org/10.2174/1871520615666150113104457
DOI https://dx.doi.org/10.2174/1871520615666150113104457 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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