Abstract
Nitric oxide (NO) is known to have dichotomous effects on cancer biology, acting as a pro- or antineoplastic agent. Low concentrations of NO are reported to promote tumor growth, whereas high NO influx acts as a potent tumor repressor, leading to cytotoxicity and apoptosis. There is increasing interest in developing NO-releasing materials as potent tumoricidal agents in which high and localized concentrations of NO may be directly released in a sustained manner to the tumor site. Nanomaterials allied to NO donors have emerged as a promising strategy in cancer treatment. In this context, this review summarizes the roles of NO in cancer biology and highlights the therapeutic potential effects of NO-releasing nanomaterials based on polymeric nanoparticles, dendritic polymers, liposomes, silica nanoparticles, metallic nanoparticles and quantum dots in combating tumor cells.
Keywords: Cancer, Cytotoxicity, Dendrimers, Diazeniumdiolates, Liposomes, Metallic nanoparticles, Nanomaterials, Nitric Oxide, Polymeric nanoparticles, Quantum dots, Silica nanoparticles, S-nitrosothiols.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Nitric Oxide Releasing Nanomaterials for Cancer Treatment: Current Status and Perspectives
Volume: 15 Issue: 4
Author(s): Amedea B. Seabra, Renata de Lima and Marcelo Calderón
Affiliation:
Keywords: Cancer, Cytotoxicity, Dendrimers, Diazeniumdiolates, Liposomes, Metallic nanoparticles, Nanomaterials, Nitric Oxide, Polymeric nanoparticles, Quantum dots, Silica nanoparticles, S-nitrosothiols.
Abstract: Nitric oxide (NO) is known to have dichotomous effects on cancer biology, acting as a pro- or antineoplastic agent. Low concentrations of NO are reported to promote tumor growth, whereas high NO influx acts as a potent tumor repressor, leading to cytotoxicity and apoptosis. There is increasing interest in developing NO-releasing materials as potent tumoricidal agents in which high and localized concentrations of NO may be directly released in a sustained manner to the tumor site. Nanomaterials allied to NO donors have emerged as a promising strategy in cancer treatment. In this context, this review summarizes the roles of NO in cancer biology and highlights the therapeutic potential effects of NO-releasing nanomaterials based on polymeric nanoparticles, dendritic polymers, liposomes, silica nanoparticles, metallic nanoparticles and quantum dots in combating tumor cells.
Export Options
About this article
Cite this article as:
Seabra B. Amedea, de Lima Renata and Calderón Marcelo, Nitric Oxide Releasing Nanomaterials for Cancer Treatment: Current Status and Perspectives, Current Topics in Medicinal Chemistry 2015; 15 (4) . https://dx.doi.org/10.2174/1568026615666150108122918
DOI https://dx.doi.org/10.2174/1568026615666150108122918 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Medicinal Chemistry Advancement in Life-Threatening Diseases
The current issue will highlight concise reports that specify ground-breaking insights, including the novel discovery of drug targets and their action mechanism or drugs of novel classes. These are projected to encourage medicinal chemistry future efforts to address the most challenging medical needs. The current issue highlights further efforts to ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The miR-183/96/182 Cluster Regulates Oxidative Apoptosis and Sensitizes Cells to Chemotherapy in Gliomas
Current Cancer Drug Targets Endogenous Factors in the Recovery of Reproductive Function After Testicular Injury and Cancer
Current Molecular Medicine Anti-Cancer Phytometabolites Targeting Cancer Stem Cells
Current Genomics Cell Elimination as a Strategy for Repair in Acute Spinal Cord Injury
Current Pharmaceutical Design The Potential Therapeutic Value of Renin-Angiotensin System Inhibitors in the Treatment of Colorectal Cancer
Current Pharmaceutical Design Nuclear Receptor SHP as a Potential Therapeutic Target for Liver Cancer
Current Cancer Therapy Reviews Small Molecule Toxins Targeting Tumor Receptors
Current Pharmaceutical Design The Molecular Basis of Notch Signaling Regulation: A Complex Simplicity
Current Molecular Medicine A Synopsis on the Role of Human Papilloma Virus Infection in Cervical Cancer
Current Drug Metabolism Inhibitors of HDACs - Effective Drugs Against Cancer?
Current Cancer Drug Targets Current Clinical Applications of Botulinum Toxin
Current Pharmaceutical Design Inflammatory Mediators Hold the Key to Dendritic Cell Suppression and Tumor Progression
Current Medicinal Chemistry Potential of Nanocarriers in Genetic Immunization
Recent Patents on Drug Delivery & Formulation Design, Synthesis and Structure-Activity Relationship Studies of Novel 4 (1-adamantyl) Phenyl Analogues as HIF-1α Inhibitors
Medicinal Chemistry Dimeric Approaches to Anti-Cancer Chemotherapeutics
Anti-Cancer Agents in Medicinal Chemistry Anlotinib Inhibits Cell Proliferation, Migration and Invasion via Suppression of c-Met Pathway and Activation of ERK1/2 Pathway in H446 Cells
Anti-Cancer Agents in Medicinal Chemistry Exfoliated Epithelial Cells: A Non-Invasive way to Evaluate the Physiological State of Gastrointestinal Epithelium
Recent Patents on Biomedical Engineering (Discontinued) MicroRNA-21: From Cancer to Cardiovascular Disease
Current Drug Targets Advances of Inorganic Materials in the Detection and Therapeutic Uses against Coronaviruses
Current Medicinal Chemistry Dimer and Tetramer of Gallic Acid: Facile Synthesis, Antioxidant and Antiproliferative Activities
Letters in Drug Design & Discovery