Abstract
Total synthesis of three Febuxostat metabolites, named 67M-1, 67M-2, and 67M-4,is described in this article. Through condensation of the key intermediate compound A with different side chains, and then oxidation and hydrolysis, we obtained three target compounds with an overall yield of 19.5%-28.0%.
Keywords: Febuxostat, three metabolites, total synthesis.
Graphical Abstract
Letters in Organic Chemistry
Title:Synthesis of the Major Metabolites of Febuxostat
Volume: 12 Issue: 3
Author(s): Xiao Long Li, Rui Qiu, Wei Li Wan, Xu Cheng, Li Hai and Yong Wu
Affiliation:
Keywords: Febuxostat, three metabolites, total synthesis.
Abstract: Total synthesis of three Febuxostat metabolites, named 67M-1, 67M-2, and 67M-4,is described in this article. Through condensation of the key intermediate compound A with different side chains, and then oxidation and hydrolysis, we obtained three target compounds with an overall yield of 19.5%-28.0%.
Export Options
About this article
Cite this article as:
Li Long Xiao, Qiu Rui, Wan Li Wei, Cheng Xu, Hai Li and Wu Yong, Synthesis of the Major Metabolites of Febuxostat, Letters in Organic Chemistry 2015; 12 (3) . https://dx.doi.org/10.2174/1570178612666150108000805
DOI https://dx.doi.org/10.2174/1570178612666150108000805 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers