摘要
许多研究表明,趋化因子受体3,趋化因子受体5,趋化因子受体6和趋化因子受体7是1型糖尿病(T1D)的决定性因素,特别是在自身免疫性疾病和细胞破坏。尤其是循环趋化因子10水平(趋化因子受体3配体)在1型糖尿病患者中含量高,这表明趋化因子10可能是1型糖尿病的一个候选预测指标。阻断趋化因子10/趋化因子受体3轴在新发病的糖尿病似乎是对1型糖尿病治疗一个潜在的战略方法。在1型糖尿病实验设置中已经尝试调节或阻断趋化因子受体5,趋化因子受体6和趋化因子受体7趋化因子受体。更多的研究有必要去评价细胞因子、趋化因子和发病机制之间的相互作用以及1型糖尿病的治疗。
关键词: 趋化因子10
图形摘要
Current Drug Targets
Title:CXCR3, CXCR5, CXCR6, and CXCR7 in Diabetes
Volume: 17 Issue: 5
Author(s): Poupak Fallahi, Alda Corrado, Andrea Di Domenicantonio, Giada Frenzilli, Alessandro Antonelli and Silvia Martina Ferrari
Affiliation:
关键词: 趋化因子10
摘要: Many studies have suggested that CXCR3, CXCR5, CXCR6 and CXCR7 chemokine receptors are determinant in type 1 diabetes (T1D), expecially in autoimmunity and β-cell destruction. In particular circulating CXCL10 level (the ligand of CXCR3) is high in T1D patients, and this suggests that CXCL10 may be a candidate for a predictive marker of T1D. Blocking the CXCL10/CXCR3 axis in newly onset of diabetes seems to be a potential strategy for the therapy of T1D. Attempts have been done in modulating or blocking CXCR5, CXCR6 and CXCR7 chemokine receptors in experimental settings of T1D. More researches are necessary to evaluate the interplay among cytokines, chemokines and the pathogenesis and therapy of T1D.
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Cite this article as:
Poupak Fallahi, Alda Corrado, Andrea Di Domenicantonio, Giada Frenzilli, Alessandro Antonelli and Silvia Martina Ferrari , CXCR3, CXCR5, CXCR6, and CXCR7 in Diabetes, Current Drug Targets 2016; 17 (5) . https://dx.doi.org/10.2174/1389450115666141229153949
DOI https://dx.doi.org/10.2174/1389450115666141229153949 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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