摘要
胃肠道和肝脏的癌症是世界范围内最常见的癌症之一。虽然在过去的十年中,在改善病人早期检测和整体生存率上,已经取得了巨大的成就,但是由于耐药性和副作用,当前可用的治疗方法仍不佳。在癌症治疗中,细胞凋亡是最理想的一种程序性细胞死亡。通过消除不必要的和不想要的细胞,细胞凋亡在发展发育,生理和体内平衡中起着至关重要的作用。最近的研究表明, 诱导细胞凋亡疗法是一种安全、有效的抗癌方法。从而可能成为癌症治疗最重要的领域之一。在本综述中,作者概述凋亡系统在多细胞生物的最新进展,总结诱导细胞凋亡疗法在胃肠道和肝脏癌症的治疗策略。
关键词: 细胞凋亡,靶向治疗,胃肠癌,肝癌
Current Gene Therapy
Title:Apoptosis-Induction is A Novel Therapeutic Strategy for Gastrointestinal and Liver Cancers
Volume: 15 Issue: 2
Author(s): Fei Wang, Haizhong Wang, Xiaotian Sun and Min Li
Affiliation:
关键词: 细胞凋亡,靶向治疗,胃肠癌,肝癌
摘要: Gastrointestinal and liver cancers are among the most frequently encountered cancers worldwide. Though great strides have been made in improving the early detection and overall patient survival in the last decade, the currently available treatment approaches remain suboptimal due to drug resistance and side effects. Apoptosis is the most desirable type of programmed cell death in cancer therapy. By eliminating unnecessary and unwanted cells, apoptosis plays a critical role in development, physiology and homeostasis. Recent studies have shown that apoptosis-inducing therapy is a safe and effective anti-cancer approach, which thus may become one of the most important areas in cancer treatment. In this review, the authors provide an overview on the apoptosis system in multicellular organisms and summarize the recent advances of apoptosis-inducing therapeutic strategy for gastrointestinal and liver cancers.
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Fei Wang, Haizhong Wang, Xiaotian Sun and Min Li , Apoptosis-Induction is A Novel Therapeutic Strategy for Gastrointestinal and Liver Cancers, Current Gene Therapy 2015; 15 (2) . https://dx.doi.org/10.2174/1566523214666141224100801
DOI https://dx.doi.org/10.2174/1566523214666141224100801 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
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