Abstract
Both direct and multistep reactions, involving the application of carbonyl compounds, e. g. oxoacids, phthalimides, 2-iodobenzamides or acylhalides, have been developed as novel synthetic routes for the preparation of 3- substituted 2,3-dihydro-1H-isoindol-1-ones, which are reviewed here. Alternatively, reductive or acid-catalyzed rearrangements of certain heterocycles lead to the formation of 3-substituted isoindolones. Asymmetric syntheses too have been described.
Keywords: isoindolones, dearomatization, heteroannulation, baylis-hillman reaction, magnesium monoperoxyphthalate, dicarbonyl compounds
Current Organic Chemistry
Title: Advanced Methods for the Synthesis of 3-Substituted 1H-Isoindol-1-Ones
Volume: 9 Issue: 13
Author(s): Geza Stajer and Ferenc Csende
Affiliation:
Keywords: isoindolones, dearomatization, heteroannulation, baylis-hillman reaction, magnesium monoperoxyphthalate, dicarbonyl compounds
Abstract: Both direct and multistep reactions, involving the application of carbonyl compounds, e. g. oxoacids, phthalimides, 2-iodobenzamides or acylhalides, have been developed as novel synthetic routes for the preparation of 3- substituted 2,3-dihydro-1H-isoindol-1-ones, which are reviewed here. Alternatively, reductive or acid-catalyzed rearrangements of certain heterocycles lead to the formation of 3-substituted isoindolones. Asymmetric syntheses too have been described.
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Cite this article as:
Stajer Geza and Csende Ferenc, Advanced Methods for the Synthesis of 3-Substituted 1H-Isoindol-1-Ones, Current Organic Chemistry 2005; 9 (13) . https://dx.doi.org/10.2174/1385272054863952
DOI https://dx.doi.org/10.2174/1385272054863952 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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