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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

FeCl3/Ultrasound Mediated Reaction of 2-aminothiophenol with Aldehydes in Water: Synthesis of 2-substituted Benzothiazoles of Pharmacological Interest

Author(s): Ponasanapalli Tirumala Venkata Ankayya Srinivas, Sallagundla Bhavani, Dandela Rambabu, Mandava Venkata Basaveswara Rao, Ravikumar Kapavarapu and Manojit Pal

Volume 12, Issue 6, 2015

Page: [457 - 465] Pages: 9

DOI: 10.2174/1570180812666141216211045

Price: $65

Abstract

We report a FeCl3•6H2O mediated green and rapid access to benzothiazole derivatives having a substituent at C-2 via the condensation of 2-aminothiophenol with various aldehydes under ultrasound irradiation and air. The reaction progressed well in water affording the expected products in good yields. Two of these compounds known to be potent anticancer agents showed good interactions with PDE4B in silico and inhibited this enzyme when tested in vitro.

Keywords: Benzothiazole, FeCl3, ultrasound, water, PDE4.

Graphical Abstract


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