Voltammetric Quantification of Antispasmodic Drug Drotaverine Hydrochloride in Human Serum

Title:Voltammetric Quantification of Antispasmodic Drug Drotaverine Hydrochloride in Human Serum

Volume: 11 Issue: 2

Author(s): Rajeev Jain and Nimisha Jadon

Affiliation:

Keywords: Drotaverine hydrochloride, HMDE, pharmaceutical preparations, human serum, adsorptive stripping voltammetric techniques.

Abstract: Drotaverine hydrochloride is an antispasmodic drug used to relieve cramps or spasms of the stomach, intestines and bladder. The electro reductive behaviour of drotaverine has been investigated and one irreversible well-defined cathodic peak was observed at -1.04 V vs. Ag/AgCl ((3.0 M) KCl). A validated, sensitive and reproducible cathodic adsorptive stripping voltammetric procedure for the trace determination of the bulk drug in human serum has been developed. The peak current showed a linear dependence with the drug concentration over the range 50 ng/mL to 25.6 μg/mL for Square-Wave Cathodic Adsorptive Stripping Voltammetry (SWCAdSV) and 0.2 μg/mL to 51.8 μg/mL for Differential Pulse Cathodic Adsorptive Stripping Voltammetry (DPCAdSV). Applicability to assay the drug in serum samples was illustrated and minimum detectability was found to be 49.83 ng/mL.

Cite this article as:

Jain Rajeev and Jadon Nimisha, Voltammetric Quantification of Antispasmodic Drug Drotaverine Hydrochloride in Human Serum, Current Pharmaceutical Analysis 2015; 11 (2) . https://dx.doi.org/10.2174/1573412911666141215214105