摘要
橄榄中齐墩果酸及相关三萜能够调节不同的信号通路,显示了广泛的药理活性:炎症、癌症或心血管疾病。特别是新兴证据揭示了齐墩果酸的降低血管疾病相关的心血管风险因素,比如高血压、肥胖和糖尿病和动脉粥样硬化。在前几年,在体外和体内开展与这些相关三萜的研究认为它们是橄榄油保护心血管的主要原因。本文综述最近的更新调查:橄榄油三萜成分与心血管疾病有关,潜在的机制和构效关系,并且广泛地分析了橄榄油三萜生物利用度的重要问题和在心血管疾病的临床应用前景。所有这些调查证据表明橄榄油中三萜有望成为对血管功能的新型治疗策略,能够有效地预防心血管疾病的进展。
关键词: 心血管疾病,齐墩果酸,橄榄中的五环三萜,血管功能
Current Medicinal Chemistry
Title:Oleanolic Acid and Related Triterpenoids from Olives on Vascular Function: Molecular Mechanisms and Therapeutic Perspectives
Volume: 22 Issue: 11
Author(s): Rosalia Rodriguez-Rodriguez
Affiliation:
关键词: 心血管疾病,齐墩果酸,橄榄中的五环三萜,血管功能
摘要: Oleanolic acid and related triterpenoids from olives modulate different signaling pathways, showing a wide range of pharmacological activities against inflammation, cancer or cardiovascular diseases. In particular, emerging evidences reveal the potential of oleanolic acid to restore vascular disorders associated to cardiovascular risk factors, i.e. hypertension, obesity and diabetes, and atherosclerosis. During the previous years, in vitro and in vivo studies with these triterpenoids have positioned them as being mainly responsible for cardiovascular risk protection traditionally associated to olive oil. This review updates recent investigations in olive oil triterpenoids function related to cardiovascular diseases, as well as the underlying mechanisms and structural implications. Important aspects of olive oil triterpenoids such as bioavailability and clinical perspectives on cardiovascular disorder are also extensively analyzed. All these investigations evidence the potential of triterpenoids from olive oil as a promising therapeutic strategy against vascular function, thus efficiently preventing the progression of cardiovascular diseases.
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Cite this article as:
Rosalia Rodriguez-Rodriguez , Oleanolic Acid and Related Triterpenoids from Olives on Vascular Function: Molecular Mechanisms and Therapeutic Perspectives, Current Medicinal Chemistry 2015; 22 (11) . https://dx.doi.org/10.2174/0929867322666141212122921
DOI https://dx.doi.org/10.2174/0929867322666141212122921 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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