炎症中的P2X7嘌呤受体的参与：自2009年以来拮抗剂一系列的更新及他们的治疗潜力

Title:Involvement of the P2X7 Purinergic Receptor in Inflammation: An Update of Antagonists Series Since 2009 and their Promising Therapeutic Potential

Volume: 22 Issue: 6

Author(s): Davy Baudelet, Emmanuelle Lipka, Regis Millet and Alina Ghinet

Affiliation:

关键词: 免疫相关疾病，免疫系统，P2X7R拮抗剂

摘要: The purinergic receptor P2X7 is highly expressed in immune peripheral and central cells suggesting its important role in numerous diseases characterized by inflammatory processes like cancer, or neurodegenerative pathologies in relation with modulation of the immune system. Thereby, antagonization of this receptor may be a hopeful therapeutic strategy to treat a large range of diseases. Indeed, selective P2X7 antagonists display beneficial anti-inflammatory, analgesic, and in some cases, anticancer properties. This article will review the involvement of P2X7 in the immune system, the update of P2X7 antagonists series since 2009 and their promising therapeutic potential for the treatment of several immune- related diseases.

Cite this article as:

Davy Baudelet, Emmanuelle Lipka, Regis Millet and Alina Ghinet , Involvement of the P2X7 Purinergic Receptor in Inflammation: An Update of Antagonists Series Since 2009 and their Promising Therapeutic Potential, Current Medicinal Chemistry 2015; 22 (6) . https://dx.doi.org/10.2174/0929867322666141212120926