摘要
苯并噻唑化合物代表了在结构上包含有一个苯环杂合了一个含有氮原子和硫原子的噻唑环的杂环体系。除了天然苯并噻唑的核心分子,合成含有苯并噻唑基团的化合物证明是一个重要的潜在疗法,因为它们显示了许多的生物活性,例如抗癌、抗菌、抗结核、抗病毒、驱虫、抗糖尿病和许多其他的生物活性。除了上述的外周或微生物的活性位点,苯并噻唑类化合物在中枢神经系统中也具有生物活性,一些含有苯并噻唑分子基团的被批准的药物已经被识别并应用于治疗各种神经系统疾病。目前正在开发的新的苯并噻唑类分子,这类分子被评估为具有多种用途,包括癫痫和神经推行性疾病例如阿尔兹海默症,亨廷顿氏舞蹈症和肌萎缩性脊髓侧索硬化症的诊断和治疗候选药物。
关键词: 阿尔兹海默病,beta淀粉粒,及萎缩性脊髓侧索硬化症,抗惊厥剂,苯并噻唑,神经保护作用
Current Medicinal Chemistry
Title:Benzothiazoles - Scaffold of Interest for CNS Targeted Drugs
Volume: 22 Issue: 6
Author(s): Lukas Hroch, Laura Aitken, Ondrej Benek, Martin Dolezal, Kamil Kuca, Frank Gunn-Moore and Kamil Musilek
Affiliation:
关键词: 阿尔兹海默病,beta淀粉粒,及萎缩性脊髓侧索硬化症,抗惊厥剂,苯并噻唑,神经保护作用
摘要: Benzothiazole compounds represent heterocyclic systems comprising a benzene ring fused with a thiazole ring containing nitrogen and sulphur in its structure. Besides the presence of a benzothiazole core in naturally occurring molecules, synthesized compounds containing a benzothiazole moiety in their structure proved to be a significant class of potential therapeutics, as they exhibit biological effects such as antitumor, antibacterial, antitubercular, antiviral, anthelmintic, antidiabetic and many others. Apart from the aforementioned peripheral or microbial active sites, benzothiazole analogues are also biologically active compounds in the central nervous system, where some approved drugs containing a benzothiazole moiety have already been identified and are used in the treatment of various neurological disorders. New benzothiazole molecules are currently under development and are being evaluated for several uses including diagnostics and as therapeutic drug candidates for the treatment of epilepsy and neurodegenerative diseases such as Alzheimer’s disease, Huntington’s disease and amyotrophic lateral sclerosis amongst others.
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Cite this article as:
Lukas Hroch, Laura Aitken, Ondrej Benek, Martin Dolezal, Kamil Kuca, Frank Gunn-Moore and Kamil Musilek , Benzothiazoles - Scaffold of Interest for CNS Targeted Drugs, Current Medicinal Chemistry 2015; 22 (6) . https://dx.doi.org/10.2174/0929867322666141212120631
DOI https://dx.doi.org/10.2174/0929867322666141212120631 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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