合成稠合的七元含氮杂环吡啶

Title:Synthesis of Pyrido-Annelated Seven-Membered N-Containing Heterocycles

Volume: 22 Issue: 9

Author(s): Koen Muylaert, Martyna Jatczak, Sven Mangelinckx and Christian V. Stevens

Affiliation:

关键词: 稠环系统，含氮杂环化合物，吡啶并[2，3 ]氮杂卓，吡啶并[3，4 ]氮杂卓，环结构，设计合成。

摘要: The pharmaceutical industry is struggling with a lack of potential drugs in the pipe line. However, there is still a great opportunity to elaborate interesting scaffolds for medicinal chemistry. Various scaffolds that hold promise are not (or little) studied or are not (or only a few times) described in literature. For the last couple of decades, a wide range of biological activities of benzodiazepine derivatives have been investigated thoroughly and have made the benzodiazepine scaffold, particularly the 1,4-benzodiazepine system, one of the most important structures for drug discovery. The substantial research on benzodiazepines has led to the synthesis of heterocycle-fused azepine derivatives with potentially new pharmacological activity. Some pyridoazepines are known to be active in the central nervous system and have a comparable activity to the well-known benzodiazepine scaffolds, which make the synthesis and the study of pyridoazepines an important research topic.

Cite this article as:

Koen Muylaert, Martyna Jatczak, Sven Mangelinckx and Christian V. Stevens , Synthesis of Pyrido-Annelated Seven-Membered N-Containing Heterocycles, Current Medicinal Chemistry 2015; 22 (9) . https://dx.doi.org/10.2174/0929867322666141212114856