Abstract
Histone deacetylases (HDACs) have recently emerged as key elements in epigenetic control of gene expression. Due to the implication of HDACs in a variety of diseases ranging from cancer to neurodegenerative disorder, HDAC inhibitors have received increased attention in recent years. Over the last few decades, a myriad of HDAC inhibitors containing a wide variety of structural features have been identified from natural sources. Here, we review the discovery, synthesis, biological properties, and modes of action of these naturally occurring HDAC inhibitors and consider their implications for future research.
Keywords: Epigenetics, Histone deacetylase inhibitor, Histone modification, Isoform selectivity, Natural product.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:An Overview of Naturally Occurring Histone Deacetylase Inhibitors
Volume: 14 Issue: 24
Author(s): Bumki Kim and Jiyong Hong
Affiliation:
Keywords: Epigenetics, Histone deacetylase inhibitor, Histone modification, Isoform selectivity, Natural product.
Abstract: Histone deacetylases (HDACs) have recently emerged as key elements in epigenetic control of gene expression. Due to the implication of HDACs in a variety of diseases ranging from cancer to neurodegenerative disorder, HDAC inhibitors have received increased attention in recent years. Over the last few decades, a myriad of HDAC inhibitors containing a wide variety of structural features have been identified from natural sources. Here, we review the discovery, synthesis, biological properties, and modes of action of these naturally occurring HDAC inhibitors and consider their implications for future research.
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Cite this article as:
Kim Bumki and Hong Jiyong, An Overview of Naturally Occurring Histone Deacetylase Inhibitors, Current Topics in Medicinal Chemistry 2014; 14 (24) . https://dx.doi.org/10.2174/1568026615666141208105614
DOI https://dx.doi.org/10.2174/1568026615666141208105614 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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