Synthetic Strategy and Biological Activity of A-ring Stereoisomers of 1,25- Dihydroxyvitamin D₃ and C2-Modified Analogues

Title:Synthetic Strategy and Biological Activity of A-ring Stereoisomers of 1,25- Dihydroxyvitamin D₃ and C2-Modified Analogues

Volume: 14 Issue: 21

Author(s): Toshie Fujishima, Tsutomu Suenaga and Takato Nozaki

Affiliation:

Keywords: Analogue, Chemical synthesis, Hormone, Nuclear receptor, Steroid, Vitamin.

Abstract: The hormonally active form of vitamin D₃, 1α,25-dihydroxyvitamin D₃ (1a), has a wide variety of biological activities and its major molecular target is considered to be the vitamin D receptor (VDR). The A-ring stereoisomers of 1a as well as its C2-modified analogues, which have different stereochemistry at the C1 and/or C3 hydroxy groups, are of interest since recent metabolic studies have shown that catabolism could occur through A-ring modification. In this review, a practical and versatile synthesis of the A-ring enyne precursors by the convergent method of Trost and coworkers, which is needed to construct all possible A-ring stereoisomers of 1,25-dihydroxyvitamin D₃ (1a-d), and the C2-modified analogues (4a-d, 5a-d, 6a-d and 7a-d) is described. A strategy for the synthesis and evaluation of all possible A-ring stereoisomers of 1a and their A-ring modified analogues is important, and this will stimulate synthesis and biological studies into vitamin D.

Cite this article as:

Fujishima Toshie, Suenaga Tsutomu and Nozaki Takato, Synthetic Strategy and Biological Activity of A-ring Stereoisomers of 1,25- Dihydroxyvitamin D₃ and C2-Modified Analogues, Current Topics in Medicinal Chemistry 2014; 14 (21) . https://dx.doi.org/10.2174/1568026615666141208102907