Abstract
A series of new chiral bifunctional Ferrocenylphosphines was designed, synthesized and applied for the asymmetric aza-Morita-Baylis-Hillman reaction of N-sulfonated imines with methyl vinyl ketone (MVK). The reaction proceeded under mild conditions to afford the desired aza-MBH adducts in moderate to high yields with up to 56% ee value.
Keywords: aza-MBH adducts, aza-Morita-Baylis-Hillman reaction, chiral bifunctional ferrocenylphosphines, organocatalyst.
Graphical Abstract
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
40