摘要
早发性阿尔茨海默病(EOAD)的状况罕见,经常与遗传因素联系在一起。基因检测连同生物标记物测试的推广促进了对临床丰富的EOAD的更广泛的识别。然而,尽管在EOAD诱发基因的建立方面做出了很大的努力,但是非典型疾病的描述和临床特征仍是临床医师面临的诊断和治疗的挑战。这篇综述旨在对EOAD的文献数据提供广泛的评估,提高EOAD的知识和理解,强调他们对病人和看护人的重大影响及影响公共策略。定义基于证据的治疗方式将是至关重要的。
关键词: 阿尔茨海默,临床的,早发型,神经影像,公共策略
Current Alzheimer Research
Title:Clinical, Genetic, and Neuroimaging Features of Early Onset Alzheimer Disease: The Challenges of Diagnosis and Treatment
Volume: 11 Issue: 10
Author(s): Antonella Alberici, Alberto Benussi, Enrico Premi, Barbara Borroni and Alessandro Padovani
Affiliation:
关键词: 阿尔茨海默,临床的,早发型,神经影像,公共策略
摘要: Early Onset Alzheimer Disease (EOAD) is a rare condition, frequently associated with genetic causes. The dissemination of genetic testing along with biomarker determinations have prompted a wider recognition of EOAD in experienced clinical settings. However, despite the great efforts in establishing the contribution of causative genes to EOAD, atypical disease presentation and clinical features still makes its diagnosis and treatment a challenge for the clinicians. This review aims to provide an extensive evaluation of literature data on EOAD, in order to improve understanding and knowledge of EOAD, underscore its significant impact on patients and their caregivers and influence public policies. This would be crucial to define the urgency of evidence-based treatment approaches.
Export Options
About this article
Cite this article as:
Antonella Alberici, Alberto Benussi, Enrico Premi, Barbara Borroni and Padovani Alessandro, Clinical, Genetic, and Neuroimaging Features of Early Onset Alzheimer Disease: The Challenges of Diagnosis and Treatment, Current Alzheimer Research 2014; 11 (10) . https://dx.doi.org/10.2174/1567205011666141107151606
DOI https://dx.doi.org/10.2174/1567205011666141107151606 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Structure of Glutamate Receptors
Current Drug Targets <i>Nigella sativa</i> – A Functional Spice From A Pharaoh’s Tomb to Modern Healthcare
The Natural Products Journal Cannabidiol Adverse Effects and Toxicity
Current Neuropharmacology Assessment of Memory Impairment in Early Diagnosis of Alzheimer’s Disease
Current Alzheimer Research Pharmacology and Therapeutics of Gabapentin in the Treatment of Psychiatric Disorders; Present and Future Perspectives
Current Neuropharmacology The Need to Avoid the Routine Use of Episiotomy
Current Women`s Health Reviews Clinical Risk Management of Interactions Between Natural Products and Drugs
Current Drug Metabolism A Genetic Dissection of Antipsychotic Induced Movement Disorders
Current Medicinal Chemistry Nociceptin/Orphanin FQ Peptide Receptors: Pharmacology and Clinical Implications
Current Drug Targets GABA-A Receptor Complex and Memory Processes
Current Topics in Medicinal Chemistry Novel Pyrimidine based Semicarbazones: Confirmation of Four Binding Site Pharmacophoric Model Hypothesis for Antiepileptic Activity
Central Nervous System Agents in Medicinal Chemistry Autoimmunity and Frontotemporal Dementia
Current Alzheimer Research The Medical Implications of Gastrointestinal Vagal Afferent Pathways in Nausea and Vomiting
Current Pharmaceutical Design Preface
Current Drug Targets - CNS & Neurological Disorders Dysiherbaine: A New Generation of Excitatory Amino Acids of Marine Origin
Central Nervous System Agents in Medicinal Chemistry Voltage-Gated Calcium Channels as Targets for the Treatment of Chronic Pain
Current Drug Targets - CNS & Neurological Disorders Kynurenic Acid and Neuroprotective Activity of the Ketogenic Diet in the Eye
Current Medicinal Chemistry Patent Selections:
Recent Patents on Anti-Cancer Drug Discovery Applied Computational Techniques on Schizophrenia Using Genetic Mutations
Current Topics in Medicinal Chemistry Molecular Modeling Used to Evaluate CYP2C9-Dependent Metabolism: Homology Modeling, Molecular Dynamics and Docking Simulations
Current Drug Metabolism