摘要
早发性阿尔茨海默病(EOAD)的状况罕见,经常与遗传因素联系在一起。基因检测连同生物标记物测试的推广促进了对临床丰富的EOAD的更广泛的识别。然而,尽管在EOAD诱发基因的建立方面做出了很大的努力,但是非典型疾病的描述和临床特征仍是临床医师面临的诊断和治疗的挑战。这篇综述旨在对EOAD的文献数据提供广泛的评估,提高EOAD的知识和理解,强调他们对病人和看护人的重大影响及影响公共策略。定义基于证据的治疗方式将是至关重要的。
关键词: 阿尔茨海默,临床的,早发型,神经影像,公共策略
Current Alzheimer Research
Title:Clinical, Genetic, and Neuroimaging Features of Early Onset Alzheimer Disease: The Challenges of Diagnosis and Treatment
Volume: 11 Issue: 10
Author(s): Antonella Alberici, Alberto Benussi, Enrico Premi, Barbara Borroni and Alessandro Padovani
Affiliation:
关键词: 阿尔茨海默,临床的,早发型,神经影像,公共策略
摘要: Early Onset Alzheimer Disease (EOAD) is a rare condition, frequently associated with genetic causes. The dissemination of genetic testing along with biomarker determinations have prompted a wider recognition of EOAD in experienced clinical settings. However, despite the great efforts in establishing the contribution of causative genes to EOAD, atypical disease presentation and clinical features still makes its diagnosis and treatment a challenge for the clinicians. This review aims to provide an extensive evaluation of literature data on EOAD, in order to improve understanding and knowledge of EOAD, underscore its significant impact on patients and their caregivers and influence public policies. This would be crucial to define the urgency of evidence-based treatment approaches.
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Antonella Alberici, Alberto Benussi, Enrico Premi, Barbara Borroni and Padovani Alessandro, Clinical, Genetic, and Neuroimaging Features of Early Onset Alzheimer Disease: The Challenges of Diagnosis and Treatment, Current Alzheimer Research 2014; 11 (10) . https://dx.doi.org/10.2174/1567205011666141107151606
DOI https://dx.doi.org/10.2174/1567205011666141107151606 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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