Synthesis and Biological Activity of Substituted-4,5,6,7-tetrahydrothieno Pyridines: A Review

Title:Synthesis and Biological Activity of Substituted-4,5,6,7-tetrahydrothieno Pyridines: A Review

Volume: 14 Issue: 12

Author(s): Jaiprakash N. Sangshetti, Abhay S. Zambare, Firoz A. Kalam Khan, Indrajeet Gonjari and Zahid Zaheer

Affiliation:

Keywords: 4, 5, 6, 7-Tetrahydrothieno pyridine, biological activities, lead molecules, clinical development.

Abstract: 4,5,6,7-Tetrahydrothieno pyridine is an important class of heterocyclic nucleus. Various 4,5,6,7-tetrahydrothieno pyridine derivatives have been synthesized and evaluated for various biological activities in different models with desired findings. Some analogs have shown potent biological activities and may be considered as lead molecule for the development of future drugs. Number of drug molecules are available in the market and many molecules are in clinical development containing 4,5,6,7-tetrahydrothieno pyridine nucleus as an important core. This review is an attempt to organize the chemical and biological aspects of 4,5,6,7-tetrahydrothieno pyridine analogs reported in last 20 year to till date. Review mainly focuses on the important role of the core in synthesis of drug or drug intermediates giving emphasis on synthetic schemes and biological activities of the different 4,5,6,7-tetrahydrothieno pyridine analogs.

Cite this article as:

Sangshetti N. Jaiprakash, Zambare S. Abhay, Khan A. Kalam Firoz, Gonjari Indrajeet and Zaheer Zahid, Synthesis and Biological Activity of Substituted-4,5,6,7-tetrahydrothieno Pyridines: A Review, Mini-Reviews in Medicinal Chemistry 2014; 14 (12) . https://dx.doi.org/10.2174/1389557514666141106131425