摘要
骨吸收增加和骨质疏松性骨折风险增加常见于免疫系统疾病病人,主要是炎症引起的风湿性疾病,因此这些病人常采用糖皮质激素治疗,因为糖皮质激素有很强的抗炎效果。在继发性骨质疏松症中,糖皮质激素诱导的骨质疏松症是最常见,最严重的,并且长期糖皮质激素治疗已经被认为是引起风湿疾病患者骨质疏松症的高危因素。然而,现在的研究表明炎症引起的风湿疾病病人发生骨质疏松症的发病机理与很多因素相关。尤其是,骨免疫学新的研究发现骨头和免疫力之间有着非常复杂的关系,这暗示炎症本身,通过促炎作用和osteoclastogenic因子的过度表达,促进骨吸收导致骨的脆性增加。因此,通过控制系统性炎症,可能也会导致风湿性疾病患者骨量的流失。从这个观点出发,我们重新审视了糖皮质激素在风湿性疾病患者骨头的作用,因此糖皮质激素将不再是骨头的敌而是最终可以成为通过控制疾病和炎症减少骨质疏松风险的一个潜在工具。
关键词: 骨头,糖皮质激素,炎症,骨质疏松症,风湿性疾病,转化医学
Current Medicinal Chemistry
Title:Glucocorticoids in Patients with Rheumatic Diseases: Friends or Enemies of Bone?
Volume: 22 Issue: 5
Author(s): Fedra Ciccarelli, Massimo De Martinis and Lia Ginaldi
Affiliation:
关键词: 骨头,糖皮质激素,炎症,骨质疏松症,风湿性疾病,转化医学
摘要: Increased bone resorption and enhanced risk of osteoporotic fractures are often reported in patients with diseases having immune system involvement, mainly inflammatory rheumatic diseases, for which glucocorticoids are more often prescribed because of their powerful antinflammatory effects. Among secondary osteoporosis, glucocorticoidinduced osteoporosis is the most common and severe form, and up to now prolonged glucocorticoid therapy has been considered the most important osteoporotic risk factor in rheumatic patients. However, it is now clear that the pathogenesis of osteoporosis in inflammatory rheumatic diseases is mediated by several factors. In particular, new discoveries within osteoimmunology concerning the complex relationship between bone and immunity, suggest that inflammation itself, through proinflammatory and osteoclastogenic cytokine overexpression, promotes bone resorption leading to increased skeletal fragility. Therefore, by controlling systemic inflammation, it is also possible to reduce the loss of bone mass which accompanies rheumatic diseases. From this point of view, we critically revisit the effects of glucocorticoids on bone in rheumatic diseases, in which they should be seen not just as an enemy of the bone health but eventually as a potential therapeutic tool capable of reducing the risk of osteoporosis by controlling disease activity and inflammation.
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Cite this article as:
Fedra Ciccarelli, Massimo De Martinis and Lia Ginaldi , Glucocorticoids in Patients with Rheumatic Diseases: Friends or Enemies of Bone?, Current Medicinal Chemistry 2015; 22 (5) . https://dx.doi.org/10.2174/0929867321666141106125051
DOI https://dx.doi.org/10.2174/0929867321666141106125051 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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