微小RNA在骨细胞分化和骨代谢紊乱中的作用

Title:Role of microRNAs in Osteoblasts Differentiation and Bone Disorders

Volume: 22 Issue: 6

Author(s): Yasir Arfat, Wei-Zhong Xiao, Munazza Ahmad, Fan Zhao, Di-Jie Li, Yu-Long Sun, Lifang Hu, Chen Zhihao, Ge Zhang, Salman Iftikhar, Peng Shang, Tuan-Ming Yang and Ai-Rong Qian

Affiliation:

关键词: 骨紊乱，微小RNA，骨细胞分化，信号通路

摘要: Advanced studies of single stranded endogenous ~22 nt microRNAs (miRNAs) have demonstrated their diverse biological functions including control of cell differentiation, cell cycle and pathological conditions. Recent studies suggest the potential application of miRNAs in stem cell engineering. miRNAs play a vital role as post-transcriptional regulators of gene expression which controls osteoblasts-mediated bone formation and osteoclasts related bone remodeling. Transcriptional and post-transcriptional mechanisms regulate the differentiation of osteoblasts and osteogenesis. The differentiation of osteoblasts is a key step in the development of skeletal muscles and it is involved in triggering the signaling pathways. Signaling pathways like TGFβ, BMP and Wnt are regulated by miRNAs which in turn, are shown to be associated with bone dynamics and bone disorders. This recap highlights the role of miRNAs in osteoblasts differentiation and emphasizes their potential therapeutic role in metabolic bone disorders.

Cite this article as:

Yasir Arfat , Wei-Zhong Xiao , Munazza Ahmad , Fan Zhao , Di-Jie Li , Yu-Long Sun , Lifang Hu , Chen Zhihao , Ge Zhang , Salman Iftikhar , Peng Shang , Tuan-Ming Yang and Ai-Rong Qian , Role of microRNAs in Osteoblasts Differentiation and Bone Disorders, Current Medicinal Chemistry 2015; 22 (6) . https://dx.doi.org/10.2174/0929867321999141106121227