摘要
半胱氨酸蛋白酶家族成员在多种关键细胞过程中有重要的作用。由于半胱氨酸蛋白酶参与复杂的蛋白水解途径,从而导致了在癌症中对其畸变影响分析的困难性。然而,有大量关于该家族的不同成员参与不同类型癌症的数据。半胱氨酸蛋白酶会促进肿瘤的转移和发展,也会增加特种肿瘤的侵袭力。他们被称为药物靶点和癌症易感性生物标记物。这意味着畸形蛋白酶的活性和蛋白表达方式也许与肿瘤的标记有关。该综述表明半胱氨酸蛋白酶对癌症潜在的不同机制的影响是毋庸置疑的。因此,他们可以作为未来研究中的潜在靶点,并且被认为在对抗癌症中起关键作用。
关键词: 凋亡,钙激活酶,癌症,半胱天冬酶,组织蛋白酶,半胱氨酸蛋白酶
Current Medicinal Chemistry
Title:Involvement of Cysteine Proteases in Cancer
Volume: 22 Issue: 8
Author(s): Jerzy Gora and Rafal Latajka
Affiliation:
关键词: 凋亡,钙激活酶,癌症,半胱天冬酶,组织蛋白酶,半胱氨酸蛋白酶
摘要: The cysteine protease family members play important roles in various pivotal cellular processes. The difficulty in the analysis of the effects of cysteine protease aberrations in cancer comes as a result of the fact that they take part in complex proteolytic pathways. Nevertheless, there is a vast amount of data regarding the involvement of distinct members of this family in divergent types of cancer. Cysteine proteases assist migration and development of the disease, as well as increase the invasiveness of particular kinds of tumors. They are designated as both drug targets, as well as cancer susceptibility biomarkers. This implies that the abnormalities in their activity and expression patterns may be associated with the hallmarks of cancer. This review demonstrates that the influence of cysteine proteases on different mechanisms underlying cancer is undisputable. Thus, they are potent targets for future study and should be recognized as key players in the fight against cancer.
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Cite this article as:
Jerzy Gora and Rafal Latajka , Involvement of Cysteine Proteases in Cancer, Current Medicinal Chemistry 2015; 22 (8) . https://dx.doi.org/10.2174/0929867321666141106115624
DOI https://dx.doi.org/10.2174/0929867321666141106115624 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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