Abstract
A novel series of coumarin fused benzothiazepines has been synthesized via coupling of oaminothiophenol with in situ generated 3-benzylidenechroman-2,4-diones. These novel compounds were screened for their in vitro antioxidant activity against free radical form of ABTS and cytotoxic activity against U87 human glioma cells. Molecular modeling and QSAR analysis were performed to explore comprehensive structure-activity relationships.
Keywords: Anticancererous, antioxidant, coumarin fused 1, 5-benzothiazepines, reactive oxygen species, structure-activity relationships.
Graphical Abstract
Mini-Reviews in Organic Chemistry
Title:Synthesis and SARs of Coumarin Fused 1,5-Benzothiazepines as Novel Anticancer and Antioxidant Agents
Volume: 12 Issue: 1
Author(s): Mazaahir Kidwai, Roona Poddar, Arti Jain, Rakesh Kumar and Pratibha M. Luthra
Affiliation:
Keywords: Anticancererous, antioxidant, coumarin fused 1, 5-benzothiazepines, reactive oxygen species, structure-activity relationships.
Abstract: A novel series of coumarin fused benzothiazepines has been synthesized via coupling of oaminothiophenol with in situ generated 3-benzylidenechroman-2,4-diones. These novel compounds were screened for their in vitro antioxidant activity against free radical form of ABTS and cytotoxic activity against U87 human glioma cells. Molecular modeling and QSAR analysis were performed to explore comprehensive structure-activity relationships.
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Kidwai Mazaahir, Poddar Roona, Jain Arti, Kumar Rakesh and Luthra M. Pratibha, Synthesis and SARs of Coumarin Fused 1,5-Benzothiazepines as Novel Anticancer and Antioxidant Agents, Mini-Reviews in Organic Chemistry 2015; 12 (1) . https://dx.doi.org/10.2174/1570193X11666141029004602
DOI https://dx.doi.org/10.2174/1570193X11666141029004602 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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