斑马鱼：来自自然界的癌症靶向疗法的预测模型

Title:Zebrafish: Predictive Model for Targeted Cancer Therapeutics from Nature

Volume: 14 Issue: 8

Author(s): Nursafwana Syazwani Zulkhernain, Soo Hwang Teo, Vyomesh Patel and Pei Jean Tan

Affiliation:

关键词: 天然产物，新颖的药物靶点，信号通路，癌症靶向治疗，目标识别，斑马鱼表型分析

摘要: Targeted therapy, the treatment of cancer based on an underlying genetic alteration, is rapidly gaining favor as the preferred therapeutic approach. To date, although natural products represent a rich resource of bio-diverse drug candidates, only a few have been identified to be effective as targeted cancer therapies largely due to the incompatibilities to current high-throughput screening methods. In this article, we review the utility of a zebrafish developmental screen for bioactive natural product-based compounds that target signaling pathways that are intimately shared with those in humans. Any bioactive compound perturbing signaling pathways identified from phenotypic developmental defects in zebrafish embryos provide an opportunity for developing targeted therapies for human cancers. This model provides a promising tool in the search for targeted cancer therapeutics from natural products.

Cite this article as:

Nursafwana Syazwani Zulkhernain, Soo Hwang Teo, Vyomesh Patel and Tan Jean Pei, Zebrafish: Predictive Model for Targeted Cancer Therapeutics from Nature, Current Cancer Drug Targets 2014; 14 (8) . https://dx.doi.org/10.2174/1568009614666141028121347