粘膜细菌疫苗的临床视野的扩展：目前的证据和未来的前景

Title:Extending the Clinical Horizons of Mucosal Bacterial Vaccines: Current Evidence and Future Prospects

Volume: 15 Issue: 12

Author(s): Silvia Sanchez-Ramon, Rebeca Perez de Diego, Romina Dieli-Crimi and Jose-Luis Subiza

Affiliation:

关键词: 免疫调节，粘膜免疫系统，粘膜菌苗，复发性感染

摘要: Antibiotics remain the mainstay of treatment for infectious diseases, but the growing frequency of antibiotic resistance represents a major concern for healthcare worldwide. The use of antibiotics in recurrent infections raises other issues, such as their limitations for treating diverse microorganisms, deleterious effects on the microbiota of the patient and potential adverse effects. In recent years, progress has been made towards the development of novel polybacterial vaccines administered via the mucosal route. These drugs target both the innate and adaptive immune systems, at the actual point of entry of most pathogens. In addition to boosting immune responses, mucosal bacterial vaccines have an intriguing immunomodulatory activity that does not compromise their efficacy against infectious agents. We review here the current clinical evidence concerning the efficacy and safety of these mucosal vaccines for the prevention and treatment of recurrent infection. We also provide an overview completing the landscape of the potential clinical uses of these active biological agents.

Cite this article as:

Sanchez-Ramon Silvia, Diego Perez de Rebeca, Dieli-Crimi Romina and Subiza Jose-Luis, Extending the Clinical Horizons of Mucosal Bacterial Vaccines: Current Evidence and Future Prospects, Current Drug Targets 2014; 15 (12) . https://dx.doi.org/10.2174/1389450115666141020160705