Chemo-Enzymatic Synthesis of a Trisaccharide-Linked Peptide Aimed at Improved Drug-Delivery

Ken   D.   Johnstone; Manuela      Dieckelmann; Michael   P.   Jennings; Istvan      Toth; Joanne   T.   Blanchfield

doi:10.2174/1567201054367977

Abstract

The glycosyltransferase enzyme LgtA, derived from the bacterial pathogen Neisseria meningitidis, was utilised in the chemo-enzymatic synthesis of a trisaccharide-linked endomorphin peptide drug candidate.

Keywords: glycosyltransferase, oligosaccharide, chemo-enzymatic, glycopeptide, solid-phase synthesis, endomorphin, peptide drug delivery, drug targeting

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Current Drug Delivery

Title: Chemo-Enzymatic Synthesis of a Trisaccharide-Linked Peptide Aimed at Improved Drug-Delivery

Volume: 2 Issue: 3

Author(s): Ken D. Johnstone, Manuela Dieckelmann, Michael P. Jennings, Istvan Toth and Joanne T. Blanchfield

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Keywords: glycosyltransferase, oligosaccharide, chemo-enzymatic, glycopeptide, solid-phase synthesis, endomorphin, peptide drug delivery, drug targeting

Abstract: The glycosyltransferase enzyme LgtA, derived from the bacterial pathogen Neisseria meningitidis, was utilised in the chemo-enzymatic synthesis of a trisaccharide-linked endomorphin peptide drug candidate.

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Johnstone D. Ken, Dieckelmann Manuela, Jennings P. Michael, Toth Istvan and Blanchfield T. Joanne, Chemo-Enzymatic Synthesis of a Trisaccharide-Linked Peptide Aimed at Improved Drug-Delivery, Current Drug Delivery 2005; 2 (3) . https://dx.doi.org/10.2174/1567201054367977