摘要
这篇综述提出和讨论了利什曼病治疗的现状和远景,重点侧重在蛋白抑制剂的使用。提出和讨论了治疗发展的历史,第一代,第二代现代药物和使用蛋白酶抑制剂治疗利什曼病的优点和缺点。这篇报道证实了蛋白酶抑制剂作为现代利什曼病治疗的一种可替代或者补充疗法的潜在有用性。他们也支持了用多种蛋白酶抑制剂联合治疗可能对脊椎动物宿主中对抗利士曼原虫感染是有效的的这种假说。
关键词: 利什曼病,利什曼虫,蛋白酶,蛋白酶抑制剂,治疗,致病因子
Current Drug Targets
Title:Proteinase Inhibitors: A Promising Drug Class for Treating Leishmaniasis
Volume: 15 Issue: 12
Author(s): Bernardo Acacio Santini Pereira, Franklin Souza-Silva, Mariana Silva-Almeida, Raquel Santos-de-Souza, Luiz Filipe Goncalves de Oliveira, Michelle Lopes Ribeiro-Guimaraes and Carlos Roberto Alves
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关键词: 利什曼病,利什曼虫,蛋白酶,蛋白酶抑制剂,治疗,致病因子
摘要: This review presents and discusses the current status and perspectives of leishmaniasis treatment, with a special focus on the use of proteinase inhibitors. The history of treatment development, the first- and second-choice modern drugs and the advantages and disadvantages of using proteinases inhibitors as leishmanicidal treatments are presented and discussed. The reports gathered herein confirm the potential usefulness of proteinases inhibitors as an alternative or complement to the current leishmaniasis treatments. They also support the hypothesis that a combined treatment with multiple proteinase inhibitors may be efficient against Leishmania infections in vertebrate hosts.
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Pereira Acacio Santini Bernardo, Souza-Silva Franklin, Silva-Almeida Mariana, Santos-de-Souza Raquel, Oliveira Filipe Goncalves de Luiz, Ribeiro-Guimaraes Lopes Michelle and Alves Roberto Carlos, Proteinase Inhibitors: A Promising Drug Class for Treating Leishmaniasis, Current Drug Targets 2014; 15 (12) . https://dx.doi.org/10.2174/1389450115666141016150007
DOI https://dx.doi.org/10.2174/1389450115666141016150007 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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