摘要
Lactoferricin和 lactoferrampin,来源于乳清蛋白乳铁蛋白的多肽,是非常有前景的抗菌剂和当前研究热点之一。本文对这两种多肽的定位和溶解结构等给出了基本介绍。提及了包括抗病毒、抗菌、抗真菌和抗炎活性及其可能的作用机制在内的生物活性。在修饰研究方面,对有关确定他们的活性衍生物和关键氨基酸残基的研究进行了讨论。总结了在Lactoferricin和 lactoferrampin修饰方面的多种尝试,例如引入大的疏水侧链、采用特殊氨基酸合成:N-乙酰化、酰胺环、环化和肽嵌合体等。对有关Lactoferricin-lactoferrampin嵌合体的研究进行了详细讨论。涵盖了Lactoferricin和 lactoferrampin的未来前景。
关键词: 抗菌肽, lactoferrampin, lactoferricin,机制,修饰
Current Molecular Medicine
Title:Recent Studies on the Antimicrobial Peptides Lactoferricin and Lactoferrampin
Volume: 14 Issue: 9
Author(s): C. Yin, J.H. Wong and T.B. Ng
Affiliation:
关键词: 抗菌肽, lactoferrampin, lactoferricin,机制,修饰
摘要: Lactoferricin and lactoferrampin, peptides derived from the whey protein lactoferrin, are antimicrobial agents with a promising prospect and are currently one of the research focuses. In this review, a basic introduction including location and solution structures of these two peptides is given. Their biological activities encompassing antiviral, antibacterial, antifungal and anti-inflammatory activities with possible mechanisms are mentioned. In terms of modification studies, research about identification of their active derivatives and crucial amino acid residues is also discussed. Various attempts at modification of lactoferricin and lactoferrampin such as introducing big hydrophobic side-chains; employing special amino acids for synthesis; N-acetylization, amidation, cyclization and peptide chimera are summarized. The studies on lactoferricin-lactoferrampin chimera are discussed in detail. Future prospects of lactoferricin and lactoferrampin are covered.
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Cite this article as:
Yin C., Wong J.H. and Ng T.B., Recent Studies on the Antimicrobial Peptides Lactoferricin and Lactoferrampin, Current Molecular Medicine 2014; 14 (9) . https://dx.doi.org/10.2174/1566524014666141015151749
DOI https://dx.doi.org/10.2174/1566524014666141015151749 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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