P2X受体，感觉神经元和疼痛

Title:P2X Receptors, Sensory Neurons and Pain

Volume: 22 Issue: 7

Author(s): Tanja Bele and Elsa Fabbretti

Affiliation:

关键词: 三磷酸腺苷，三磷酸腺苷，痛觉过敏，伤害性感受，嘌呤信令。

摘要: Pain represents a very large social and clinical problem since the current treatment provides insufficient pain relief. Plasticity of pain receptors together with sensitisation of sensory neurons, and the role of soluble mediators released from non-neuronal cells render difficult to understand the spatial and temporal scale of pain development, neuronal responses and disease progression. In pathological conditions, ATP is one of the most powerful mediators that activates P2X receptors that behave as sensitive ATP-detectors, such as neuronal P2X3 receptor subtypes and P2X4 and P2X7 receptors expressed on non-neuronal cells. Dissecting the molecular mechanisms occurring in sensory neurons and in accessory cells allows to design appropriate tissue- and cell- targeted approaches to treat chronic pain.

Cite this article as:

Tanja Bele and Elsa Fabbretti , P2X Receptors, Sensory Neurons and Pain, Current Medicinal Chemistry 2015; 22 (7) . https://dx.doi.org/10.2174/0929867321666141011195351