潜在的喹喔啉类抗感染药物设计的研究进展

Title:Recent Advances in Design of Potential Quinoxaline Anti-Infectives

Volume: 21 Issue: 38

Author(s): Josef Jampilek

Affiliation:

关键词: 抗菌，抗真菌，抗分支杆菌药物，抗原虫药，喹喔啉，合成

摘要: Antimicrobial diazanaphthalenes are indispensable in the treatment of various infections. The quinoxaline scaffold possesses unique physicochemical properties and provides a possibility of a great number of targeted modifications. Quinoxaline-based compounds have a wide range of promising biological properties; therefore a special attention is paid to them for research and designing of new drugs. In fact, quinoxaline can be considered as a privileged structure. The scaffold can be easily and rapidly constructed, which emphasizes the significance of this favourable structure. The review is focused on recently reported potential antibacterial, antimycobacterial, antifungal and antiprotozoal agents derived from the quinoxaline scaffold, their mechanism of action and structure-activity relationships. A brief classification of synthetic pathways of quinoxaline derivatives is provided too.

Cite this article as:

Jampilek Josef, Recent Advances in Design of Potential Quinoxaline Anti-Infectives, Current Medicinal Chemistry 2014; 21 (38) . https://dx.doi.org/10.2174/0929867321666141011194825