Protective Antibodies and Endemic Dimorphic Fungi

Title: Protective Antibodies and Endemic Dimorphic Fungi

Volume: 5 Issue: 4

Author(s): J. D. Nosanchuk

Affiliation:

Keywords: histoplasma capsulatum, antibody, pathogenesis

Abstract: The host response to infection is the outcome of a complex interaction between a microbe and a hosts innate and adaptive immune system. In this context, the role of antibody in the endemic mycoses is relatively poorly understood. Recently, a monoclonal antibody to a cell surface protein has been shown to be protective in a murine histoplasmosis model. The findings with Histoplasma capsulatum may provide a paradigm for antibody protection against endemic fungi. This paper reviews the recent data on protective antibody in histoplasmosis and previous data supporting a role for antibody in protective responses in other dimorphic fungi.

Cite this article as:

Nosanchuk D. J., Protective Antibodies and Endemic Dimorphic Fungi, Current Molecular Medicine 2005; 5 (4) . https://dx.doi.org/10.2174/1566524054022530