NMR在抗菌药物的NMR设计中的作用

Title:NMR in the Design of Antibacterials

Volume: 21 Issue: 38

Author(s): Emilija Arsovska, Gregor Mali, Simona Golic Grdadolnik and Anamarija Zega

Affiliation:

关键词: 抗生素，药物发现，药物设计碎片，配体观察筛选，核磁共振波谱，固态核磁共振，靶点观察筛选

摘要: One of the most challenging areas in drug design is the area of new antibacterial drugs. Despite significant progress in target validation and screening programs, discovery of new antibacterial classes is not keeping pace with the growing threat of bacterial resistance. In this review we describe examples of the use of NMR spectroscopy methods in different phases of antibacterial drug design. First, several frequently used liquid and solid-state NMR techniques are presented, followed by a review and discussion of the application of NMR spectroscopy to the discovery of new antibacterial agents.

Cite this article as:

Arsovska Emilija, Mali Gregor, Grdadolnik Golic Simona and Zega Anamarija, NMR in the Design of Antibacterials, Current Medicinal Chemistry 2014; 21 (38) . https://dx.doi.org/10.2174/0929867321666141011193707