摘要
根据国际准则,宫颈癌(CC)的治疗包括早期的手术疗法和局部晚期疾病的化疗。转移性疾病通常采用缓和的化疗方案来治疗,但是抑制细胞生长的药物呈现了严重的副作用及显示有限的活性。因此,由肿瘤微环境或者肿瘤自身表达所干扰分子靶点的新的抗癌药物的发现为对抗这种肿瘤提供了一个可能的机会。这篇综述的目的是为了报道所有的已被临床前或临床研究的靶点。我们根据靶向治疗的NCI分类来讨论这些可能的靶点。大多数研究的分子靶标具有表皮生长因子(EGFR)和血管内皮生长因子(VEGF),这两种生长因子均涉及到宫颈癌的发病机理。抗血管生成剂的研究显示了令人鼓舞的临床疗效和可接受的毒性。其他有趣的研究结果已经通过免疫治疗策略获得。由于宫颈癌,特别是在复发性疾病中的生物学特性仍然部分未知,为了给病人提供最适合和有效的治疗方法,用来解释宫颈癌的致癌作用的机制进一步研究是必要的。
关键词: 宫颈癌,分子路径,临床前研究,靶向治疗
Current Drug Targets
Title:Cervical Cancer: Are There Potential New Targets? An Update on Preclinical and Clinical Results
Volume: 15 Issue: 12
Author(s): Federica Tomao, Chiara Di Tucci, Ludovica Imperiale, Serena Maria Boccia, Claudia Marchetti, Innocenza Palaia, Ludovico Muzii and Pierluigi Benedetti Panici
Affiliation:
关键词: 宫颈癌,分子路径,临床前研究,靶向治疗
摘要: According to international guidelines, treatment of cervical cancer (CC) consists of surgery in early stages and of chemoradiation in locally advanced disease. Metastatic disease is usually treated with palliative chemotherapeutic regimens, but cytostatic drugs present significant side effects and show limited activity. Thus, the discovery of new anticancer agents, interfering with molecular targets expressed by the tumor’s microenvironment or by the tumor cell itself, represents a possible chance for the struggle against this tumor. The aim of this review is to report all targets that have been investigated in preclinical and clinical studies. We discuss these potential targets according to “targeted therapies” NCI classification. The most investigated molecular targets have been epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF), both involved in CC etiopathogenesis. Studies with anti-angiogenetic agents showed encouraging clinical efficacy and acceptable toxicity. Other interesting results have been obtained by immunotherapeutic strategies. Since biological characteristics of CC, especially in recurrent disease, are still partially unknown, future studies are necessary to understand mechanisms involved in CC carcinogenesis, in order to give to patients the most tailored and efficient treatments.
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Tomao Federica, Tucci Di Chiara, Imperiale Ludovica, Boccia Maria Serena, Marchetti Claudia, Palaia Innocenza, Muzii Ludovico and Panici Benedetti Pierluigi, Cervical Cancer: Are There Potential New Targets? An Update on Preclinical and Clinical Results, Current Drug Targets 2014; 15 (12) . https://dx.doi.org/10.2174/1389450115666141010145547
DOI https://dx.doi.org/10.2174/1389450115666141010145547 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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