Abstract
Stereoselective formation of six-membered carbacycles with biological and pharmaceutical relevance is one of the prime research areas in modern organic synthesis. Various innovative synthetic protocols involving asymmetric C-C bond forming reactions have been developed and exploited widely. The present review attempts to elaborate the original contributions and recent advancements made in this field for the stereoselective synthesis of a diverse array of asymmetric sixmembered carbacyclic compounds employing very simple and/or advanced organocatalytic domino reactions.
Keywords: Carbacycles, cascade, C-C bond formation, domino reaction, enantioselective, Michael reaction, organocatalysis, tandem.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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