Abstract
The guanidine functional group is an important structural motif in synthesis with a wide range of interesting properties. Guanidines are frequently found in bioactive compounds; both from natural sources or from synthetic origin, these compounds are considered fundamental entities in medicinal chemistry. The relevance of these compounds fosters the efforts to explore new methodologies for the synthesis of substances based on the guanidine core. The aim of this review is to provide a survey of the types of reactions used to prepare these classes of compounds. Given the vast number of contributions to this topic, we have focused on the achievements made in the last five years and, in particular, in the synthesis of biologically relevant heterocyclic guanidine-derivatives.
Keywords: Bioactive compound, biological activities, guanidine, guanylating agents, heterocycle, synthesis.
Graphical Abstract
Current Organic Chemistry
Title:Synthetic Approaches to Heterocyclic Guanidines with Biological Activity: An Update
Volume: 18 Issue: 21
Author(s): Sandra G. Zarate, Andres G. Santana, Agatha Bastida and Julia Revuelta
Affiliation:
Keywords: Bioactive compound, biological activities, guanidine, guanylating agents, heterocycle, synthesis.
Abstract: The guanidine functional group is an important structural motif in synthesis with a wide range of interesting properties. Guanidines are frequently found in bioactive compounds; both from natural sources or from synthetic origin, these compounds are considered fundamental entities in medicinal chemistry. The relevance of these compounds fosters the efforts to explore new methodologies for the synthesis of substances based on the guanidine core. The aim of this review is to provide a survey of the types of reactions used to prepare these classes of compounds. Given the vast number of contributions to this topic, we have focused on the achievements made in the last five years and, in particular, in the synthesis of biologically relevant heterocyclic guanidine-derivatives.
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Cite this article as:
Zarate G. Sandra, Santana G. Andres, Bastida Agatha and Revuelta Julia, Synthetic Approaches to Heterocyclic Guanidines with Biological Activity: An Update, Current Organic Chemistry 2014; 18 (21) . https://dx.doi.org/10.2174/1385272819666141002004054
DOI https://dx.doi.org/10.2174/1385272819666141002004054 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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