Abstract
A mild and economical method to prepare vildagliptin had been reported with a good yield. In this paper, vildagliptin was synthesized from L-proline and 3-amino-1-adamantanol through chloride acetylation, amination, dehydration and substitution. The total yield of the target compound was 59%.
Keywords: Economical, synthesize, vildagliptin.
Graphical Abstract
Letters in Organic Chemistry
Title:A Facile and Economical Method to Synthesize Vildagliptin
Volume: 11 Issue: 10
Author(s): Yu Deng, Anmin Wang, Zhu Tao, Yingjie Chen, Xinmei Pan and Xiangnan Hu
Affiliation:
Keywords: Economical, synthesize, vildagliptin.
Abstract: A mild and economical method to prepare vildagliptin had been reported with a good yield. In this paper, vildagliptin was synthesized from L-proline and 3-amino-1-adamantanol through chloride acetylation, amination, dehydration and substitution. The total yield of the target compound was 59%.
Export Options
About this article
Cite this article as:
Deng Yu, Wang Anmin, Tao Zhu, Chen Yingjie, Pan Xinmei and Hu Xiangnan, A Facile and Economical Method to Synthesize Vildagliptin, Letters in Organic Chemistry 2014; 11 (10) . https://dx.doi.org/10.2174/1570178611666140922121805
DOI https://dx.doi.org/10.2174/1570178611666140922121805 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Hashimotos Thyroiditis: From Genes to the Disease
Current Genomics Glycogen Synthase Kinase 3 as an Anticancer Drug Target: Novel Experimental Findings and Trends in the Design of Inhibitors
Current Pharmaceutical Design Mycobacterium Tuberculosis in New Biologic Era
Current Rheumatology Reviews Antidiabetic Potential of Fabaceae Family: An Overview
Current Nutrition & Food Science Aceruloplasminemia
Current Drug Targets Chronic Hepatitis C and Alcohol Abuse: The Single Center Experience of Novi Sad - Serbia
Reviews on Recent Clinical Trials Pharmacokinetic Study and Trial for Preparation of Enteric-Coated Capsule Containing Insulinomimetic Vanadyl Compounds: Implications for Clinical Use
Mini-Reviews in Medicinal Chemistry Left Ventricular 2-[<sup>18</sup>F]-Fluoro-2-Deoxy-D-Glucose Uptake Using Modified Oral Glucose Loading Protocol With Pre-Medicated Niacin On Positron Emission Tomography/Computed Tomography - A Preliminary Study
Current Molecular Imaging (Discontinued) Prolylcarboxypeptidase Gene Expression in the Heart and Kidney: Effects of Obesity and Diabetes
Cardiovascular & Hematological Agents in Medicinal Chemistry Interatrial Block in the Modern Era
Current Cardiology Reviews 3D-QSAR analysis of MCD inhibitors by CoMFA and CoMSIA
Combinatorial Chemistry & High Throughput Screening Editorial: Nailfold Capillaroscopy in Rheumatology
Current Rheumatology Reviews In Search for the Troponin of the Kidney
Current Medicinal Chemistry Pregnancy, Physical Activity and Weight Control to Prevent Obesity and Future Chronic Disease Risk in Both Mother and Child
Current Women`s Health Reviews Circulating Advanced Oxidation Protein Products as Oxidative Stress Biomarkers and Progression Mediators in Pathological Conditions Related to Inflammation and Immune Dysregulation
Current Medicinal Chemistry Advanced Glycation End Products: A Link Between Periodontitis and Diabetes Mellitus?
Current Diabetes Reviews The Prevalence and Progression of Arterial Calcification in Patients with End-Stage Renal Disease
Vascular Disease Prevention (Discontinued) Endothelial Therapy of Atherosclerosis and its Risk Factors
Current Vascular Pharmacology Long-term Reproductive and Metabolic Consequences of PCOS
Current Diabetes Reviews Cerium and Yttrium Oxide Nanoparticles and Nano-selenium Produce Protective Effects Against H2O2-induced Oxidative Stress in Pancreatic Beta Cells by Modulating Mitochondrial Dysfunction
Pharmaceutical Nanotechnology