Abstract
The regulation of neurohypophyseal peptides secretion reflects the convergence of a large number of afferent neural pathways on vasopressinergic and oxytocinergic neurons of supraoptic (SON) and paraventricular nuclei (PVN). In addition to afferent input, vasopressin and oxytocin can also exert an autocrine regulation of neuronal activity. In fact, magnocellular neurons (MCNs) of SON and PVN are able to secrete these hormones not only at the endings of their terminal axons, but also from their dendrites and this local release, by activating a range of ion gated, ion channel and G protein coupled receptors, participate in pre- and post-synaptic modulation of neural activity of MCNs. In this review we analyzed the molecular mechanisms involved in the control of neurohypophyseal hormones secretion and related possible pharmacological targets.
Keywords: Dehydration, lactation, parturition, vasopressin, oxytocin, hypotalamo-neurohyposyeal system, molecular mechanisms, pharmacological targets.
Current Pharmaceutical Design
Title:Molecular Mechanisms Involved in the Control of Neurohypophyseal Hormones Secretion
Volume: 20 Issue: 42
Author(s): M. Iovino, E. Guastamacchia, V.A. Giagulli, B. Licchelli, E. Iovino and V. Triggiani
Affiliation:
Keywords: Dehydration, lactation, parturition, vasopressin, oxytocin, hypotalamo-neurohyposyeal system, molecular mechanisms, pharmacological targets.
Abstract: The regulation of neurohypophyseal peptides secretion reflects the convergence of a large number of afferent neural pathways on vasopressinergic and oxytocinergic neurons of supraoptic (SON) and paraventricular nuclei (PVN). In addition to afferent input, vasopressin and oxytocin can also exert an autocrine regulation of neuronal activity. In fact, magnocellular neurons (MCNs) of SON and PVN are able to secrete these hormones not only at the endings of their terminal axons, but also from their dendrites and this local release, by activating a range of ion gated, ion channel and G protein coupled receptors, participate in pre- and post-synaptic modulation of neural activity of MCNs. In this review we analyzed the molecular mechanisms involved in the control of neurohypophyseal hormones secretion and related possible pharmacological targets.
Export Options
About this article
Cite this article as:
Iovino M., Guastamacchia E., Giagulli V.A., Licchelli B., Iovino E. and Triggiani V., Molecular Mechanisms Involved in the Control of Neurohypophyseal Hormones Secretion, Current Pharmaceutical Design 2014; 20 (42) . https://dx.doi.org/10.2174/1381612820666140905150730
DOI https://dx.doi.org/10.2174/1381612820666140905150730 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Synthesis of Dihydropyridines: Patented Catalysts and Biological Applications
Recent Patents on Catalysis (Discontinued) Endothelin Receptor Antagonists: Another Potential Alternative for Cardiovascular Diseases
Current Drug Targets - Cardiovascular & Hematological Disorders Comparative Biochemical Studies of Myotoxic Phospholipase A2 From Bothrops Venom
Protein & Peptide Letters Attenuation of Hydroxyl Radical Formation by Extracted Constituent of Moringa oleifera Lam
Current Chemical Biology Review of Treatment for Cocaine Dependence
Current Drug Abuse Reviews Cellular Mechanisms in Perinatal Hypoxic-Ischemic Brain Injury
Current Pediatric Reviews The Clinical Utility of Ambulatory Blood Pressure Monitoring (ABPM): A Review
Current Hypertension Reviews Management of Acute Aluminum Phosphide Poisoning: Has Anything Changed?
Drug Metabolism Letters Adrenomedullin: Roles for Structure and Function in Cardiac or Vascular Tissues
Current Hypertension Reviews Acute Human Toxicity of Macrocyclic Lactones
Current Pharmaceutical Biotechnology An Efficient Organocatalyst for Environmentally benign Synthesis of Pyranopyrazole Derivatives in Aqueous Medium
Letters in Organic Chemistry Treatment of Takotsubo Cardiomyopathy
Current Pharmaceutical Design Patent Selections
Recent Patents on Cardiovascular Drug Discovery Opioids and Cannabinoids Interactions: Involvement in Pain Management
Current Drug Targets Hybrid Stress Testing by Adenosine Infusion and Exercise Myocardial Perfusion Imaging: A Critical Appraisal
Current Cardiology Reviews Alumina Sulfuric Acid: An Efficient Heterogeneous Catalyst for the Synthesis of Amidoalkyl Naphthols
Letters in Organic Chemistry Small Molecules as Anti-TNF Drugs
Current Medicinal Chemistry Effects of Statins on Blood Pressure: A Review of the Experimental and Clinical Evidence.
Current Vascular Pharmacology Obesity and Cardiovascular Physiology: Impact of some Pharmacological Agents
Current Vascular Pharmacology Leishmaniasis: Current Treatment and Prospects for New Drugs and Vaccines
Current Medicinal Chemistry