Cerebrospinal Fluid Flow Dynamics in Multiple Sclerosis Patients through Phase Contrast Magnetic Resonance Imaging

Title:Cerebrospinal Fluid Flow Dynamics in Multiple Sclerosis Patients through Phase Contrast Magnetic Resonance Imaging

Volume: 11 Issue: 4

Author(s): Maria Marcella Lagana, Anamika Chaudhary, Deepa Balagurunathan, David Utriainen, Paul Kokeny, Wei Feng, Pietro Cecconi, David Hubbard and E. Mark Haacke

Affiliation:

Keywords: Cerebrospinal fluid, multiple sclerosis, phase contrast mri, venous stenosis.

Abstract: We studied cerebrospinal fluid (CSF) flow dynamics at the cervical level in association with internal jugular vein (IJV) flow for 92 patients with multiple sclerosis (MS). Phase contrast magnetic resonance imaging was used to quantify flow of the CSF and major vessels (including the IJV and the carotid arteries) at the C2-C3 level in the neck. Contrast enhanced MR angiography and time-of-flight MR venography were used to subdivide MS patients into stenotic (ST) and non-stenotic (NST) populations. We evaluated: IJV flow normalized by arterial flow; CSF peaks; CSF outflow duration and its onset from systole. We tested if these variables were statistically different among different MS phenotypes and between ST and NST MS patients. The delay between the beginning of systole and the CSF outflow was higher in ST compared to NST MS. Less IJV flow was observed in ST vs NST MS. None of the measures was different between the different MS phenotypes. These results suggest that alterations of IJV morphology affect both IJV flow and CSF flow timing but not CSF flow amplitude.

Cite this article as:

Lagana Marcella Maria, Chaudhary Anamika, Balagurunathan Deepa, Utriainen David, Kokeny Paul, Feng Wei, Cecconi Pietro, Hubbard David and Haacke Mark E., Cerebrospinal Fluid Flow Dynamics in Multiple Sclerosis Patients through Phase Contrast Magnetic Resonance Imaging, Current Neurovascular Research 2014; 11 (4) . https://dx.doi.org/10.2174/1567202611666140829161410