肽脱甲酰基酶：一个新的抗菌、抗疟疾和抗癌的药开发的靶标

Title:Peptide Deformylase: A New Target in Antibacterial, Antimalarial and Anticancer Drug Discovery

Volume: 22 Issue: 2

Author(s): Jaiprakash N. Sangshetti, Firoz A. Kalam Khan and Devanand B. Shinde

Affiliation:

关键词: 抗菌，抗癌，抗疟疾，临床开发，肽脱甲酰基酶。

摘要: Peptide deformylase (PDF) is a class of metalloenzyme responsible for catalyzing the removal of the N-formyl group from N-terminal methionine following translation. PDF inhibitors are moving into new phase of drug development. Initially, PDF was considered as an important target in antibacterial drug discovery; however genome database searches have revealed PDF-like sequences in parasites (P. falciparum) and human, widening the utility of this target in antimalarial and anticancer drug discovery along with antibacterial. Using structural and mechanistic information together with high throughput screening, several types of chemical classes of PDF inhibitors with improved efficacy and specificity have been identified. Various drugs like, GSK-1322322 (Phase II), BB-83698 (Phase I), and LBM-415 (Phase I) have entered into clinical developments. Developments in the field have prompted us to review the current aspects of PDFs, especially their structures, different classes of PDF inhibitors, and molecular modeling studies. In nut shell, this review enlightens PDF as a versatile target along with its inhibitors and future perspectives of different PDF inhibitors.

Cite this article as:

Jaiprakash N. Sangshetti, Firoz A. Kalam Khan and Devanand B. Shinde , Peptide Deformylase: A New Target in Antibacterial, Antimalarial and Anticancer Drug Discovery, Current Medicinal Chemistry 2015; 22 (2) . https://dx.doi.org/10.2174/0929867321666140826115734