摘要
人类免疫缺陷病毒(HIV)感染通常会导致仅次于免疫缺陷的许多伴发疾病。感染也会影响器官系统功能。虽然抗逆转病毒疗法(ART) 是通过有效控制外围病毒载量,包括肠内、淋巴和中枢神经系统的组织等HIV病毒储存库的限制感染来减少疾病的发病率和死亡率;但是还没有被淘汰。在某种程度上,ART通过组织障碍在每个器官的低渗透率、病毒变异和受感染细胞的寿命是这些事件的基础。我们假设纳米科技是可以改善这些疾病结果的一种方法。为此,该综述讨论了多种尖端的纳米药物和纳米医学平台,他们可以用来改善ART投递。讨论的问题包括聚合物偶联药、树状聚合物、微胶粒、微脂囊、固体脂质纳米粒和聚合纳米粒是是如何被利用而达到以细胞为基底的运载系统的最佳产量。当发展完全时,此纳米医学平台有清除病毒感染库的潜质。
关键词: 树状聚合物,药物释放系统,肠相关淋巴组织,人类免疫缺陷病毒,以ART为靶向的HIV病毒储存库,微脂囊,淋巴组织,微胶粒,纳米医学,聚合纳米粒子
Current Medicinal Chemistry
Title:Development of HIV Reservoir Targeted Long Acting Nanoformulated Antiretroviral Therapies
Volume: 21 Issue: 36
Author(s): Benson J. Edagwa, Tian Zhou, JoEllyn M. McMillan, Xin-Ming Liu and Howard E. Gendelman
Affiliation:
关键词: 树状聚合物,药物释放系统,肠相关淋巴组织,人类免疫缺陷病毒,以ART为靶向的HIV病毒储存库,微脂囊,淋巴组织,微胶粒,纳米医学,聚合纳米粒子
摘要: Human immunodeficiency virus (HIV) infection commonly results in a myriad of comorbid conditions secondary to immune deficiency. Infection also affects broad organ system function. Although current antiretroviral therapy (ART) reduces disease morbidity and mortality through effective control of peripheral viral load, restricted infection in HIV reservoirs including gut, lymphoid and central nervous system tissues, is not eliminated. What underlies these events is, in part, poor ART penetrance into each organ across tissue barriers, viral mutation and the longevity of infected cells. We posit that one means to improve these disease outcomes is through nanotechnology. To this end, this review discusses a broad range of cutting-edge nanomedicines and nanomedicine platforms that are or can be used to improve ART delivery. Discussion points include how polymer-drug conjugates, dendrimers, micelles, liposomes, solid lipid nanoparticles and polymeric nanoparticles can be harnessed to best yield cell-based delivery systems. When completely developed, such nanomedicine platforms have the potential to clear reservoirs of viral infection.
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Cite this article as:
Edagwa J. Benson, Zhou Tian, McMillan M. JoEllyn, Liu Xin-Ming and Gendelman E. Howard, Development of HIV Reservoir Targeted Long Acting Nanoformulated Antiretroviral Therapies, Current Medicinal Chemistry 2014; 21 (36) . https://dx.doi.org/10.2174/0929867321666140826114135
DOI https://dx.doi.org/10.2174/0929867321666140826114135 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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