摘要
人类免疫缺陷病毒(HIV)感染通常会导致仅次于免疫缺陷的许多伴发疾病。感染也会影响器官系统功能。虽然抗逆转病毒疗法(ART) 是通过有效控制外围病毒载量,包括肠内、淋巴和中枢神经系统的组织等HIV病毒储存库的限制感染来减少疾病的发病率和死亡率;但是还没有被淘汰。在某种程度上,ART通过组织障碍在每个器官的低渗透率、病毒变异和受感染细胞的寿命是这些事件的基础。我们假设纳米科技是可以改善这些疾病结果的一种方法。为此,该综述讨论了多种尖端的纳米药物和纳米医学平台,他们可以用来改善ART投递。讨论的问题包括聚合物偶联药、树状聚合物、微胶粒、微脂囊、固体脂质纳米粒和聚合纳米粒是是如何被利用而达到以细胞为基底的运载系统的最佳产量。当发展完全时,此纳米医学平台有清除病毒感染库的潜质。
关键词: 树状聚合物,药物释放系统,肠相关淋巴组织,人类免疫缺陷病毒,以ART为靶向的HIV病毒储存库,微脂囊,淋巴组织,微胶粒,纳米医学,聚合纳米粒子
Current Medicinal Chemistry
Title:Development of HIV Reservoir Targeted Long Acting Nanoformulated Antiretroviral Therapies
Volume: 21 Issue: 36
Author(s): Benson J. Edagwa, Tian Zhou, JoEllyn M. McMillan, Xin-Ming Liu and Howard E. Gendelman
Affiliation:
关键词: 树状聚合物,药物释放系统,肠相关淋巴组织,人类免疫缺陷病毒,以ART为靶向的HIV病毒储存库,微脂囊,淋巴组织,微胶粒,纳米医学,聚合纳米粒子
摘要: Human immunodeficiency virus (HIV) infection commonly results in a myriad of comorbid conditions secondary to immune deficiency. Infection also affects broad organ system function. Although current antiretroviral therapy (ART) reduces disease morbidity and mortality through effective control of peripheral viral load, restricted infection in HIV reservoirs including gut, lymphoid and central nervous system tissues, is not eliminated. What underlies these events is, in part, poor ART penetrance into each organ across tissue barriers, viral mutation and the longevity of infected cells. We posit that one means to improve these disease outcomes is through nanotechnology. To this end, this review discusses a broad range of cutting-edge nanomedicines and nanomedicine platforms that are or can be used to improve ART delivery. Discussion points include how polymer-drug conjugates, dendrimers, micelles, liposomes, solid lipid nanoparticles and polymeric nanoparticles can be harnessed to best yield cell-based delivery systems. When completely developed, such nanomedicine platforms have the potential to clear reservoirs of viral infection.
Export Options
About this article
Cite this article as:
Edagwa J. Benson, Zhou Tian, McMillan M. JoEllyn, Liu Xin-Ming and Gendelman E. Howard, Development of HIV Reservoir Targeted Long Acting Nanoformulated Antiretroviral Therapies, Current Medicinal Chemistry 2014; 21 (36) . https://dx.doi.org/10.2174/0929867321666140826114135
DOI https://dx.doi.org/10.2174/0929867321666140826114135 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Plasminogen Activation System Promotes Neurorepair in the Ischemic Brain
Current Drug Targets Symmetry Plane Detection in Brain Image Analysis: A Survey
Current Medical Imaging Aptamers as Targeting Delivery Devices or Anti-cancer Drugs for Fighting Tumors
Current Drug Metabolism Antitumoral-Lipid-Based Nanoparticles: a Platform for Future Application in Osteosarcoma therapy
Current Pharmaceutical Design Melatonin and Respiratory Diseases: A Review
Current Topics in Medicinal Chemistry Mesenchymal Stem Cells as a Source of Dopaminergic Neurons: A Potential Cell Based Therapy for Parkinson's Disease
Current Stem Cell Research & Therapy Role of Histone Deacetylases (HDACs) in Epilepsy and Epileptogenesis
Current Pharmaceutical Design Realization Methods of Computer-aided Diagnosis System of Medical Images
Recent Patents on Engineering A Review of the Primer Approximation Multiplex PCR (PAMP) Technique for Detecting Large Scale Cancer Genomic Lesions
Current Bioinformatics Cancer Stem Cells and Colorectal Cancer: An Overview
Current Topics in Medicinal Chemistry Temozolomide: An Updated Overview of Resistance Mechanisms, Nanotechnology Advances and Clinical Applications
Current Neuropharmacology Cell-Based Assay System to Estimate the Effect of 125I Seeds on Cancer Cells: Effect of Osteopontin
Recent Patents on Anti-Cancer Drug Discovery Natural Killer Cells: Prospects in Cancer Immunotherapy
Current Immunology Reviews (Discontinued) Molecular Basis for the Neuroprotective Properties of FKBP-Binding Immunophilin Ligands
Current Medicinal Chemistry - Central Nervous System Agents p42.3 in Gastric Carcinoma: A Novel Biomarker and Promising Therapeutic Target
Letters in Drug Design & Discovery NRG1-ErbB Lost in Translation: A New Paradigm for Lung Cancer?
Current Medicinal Chemistry Mesenchymal stem cell therapy for inflammatory bowel diseases: promise and challenge
Current Stem Cell Research & Therapy Proteomics in the Search for Biomarkers of Animal Cancer
Current Protein & Peptide Science Design of Magnetic Nanoparticles-Assisted Drug Delivery System
Current Pharmaceutical Design Preclinical Development of Novel Anti-Glioma Drugs Targeting the Endoplasmic Reticulum Stress Response
Current Pharmaceutical Design