根据聚类症状表现治疗帕金森氏病中的运动和非运动症状

Title:Treatment of the Motor and Non-Motor Symptoms in Parkinson's Disease According to Cluster Symptoms Presentation

Volume: 15 Issue: 10

Author(s): Fulvio Lauretani, Antonio Saginario, Gian Paolo Ceda, Laura Galuppo, Livia Ruffini, Anna Nardelli and Marcello Maggio

Affiliation:

关键词: 聚类症状，运动症状，非运动症状，帕金森氏病，亚型，治疗

摘要: The term Parkinson’s disease has been changed in ‘Parkinson's diseases’ to describe different clinical entities observed in several studies investigating the existence of PD subtypes. PD patients could be grouped based on clinical features. By considering only motor symptoms, we can classically distinguish two groups: “ the tremorigen-form” and “akinetic- rigidity-form” where resting tremor and akinesia/bradikynesia and rigidity are the most motor predominant symptoms, respectively. Non-motor symptoms (NMSs) are practically always present during the course of the disease and some of them (constipation, depressive status, hyposmia and anxiety) could even exist before the onset of classical motor symptoms. Many other NMSs and in particular hallucinations, cognitive impairment, sleep disorders and difficulty in swallowing strongly affect the advanced stage of disease, and represent a real therapeutic challenge when these symptoms are simultaneously present with different severity. If not adequately treated, they can increase the risk of hospitalization and admissions in nursing home, and profoundly and negatively influence the quality of life and participation in social activity of these patients. PD subtypes according to the combination of motor and non-motor symptoms have been recently proposed. This classification derives from cluster analysis which permits to identify statistically distinct subtypes of Parkinsonian patients according to the relevance of both motor and non-motor symptoms. In this point of view, we propose a schematic therapeutic approach of motor and non-motor symptoms in Parkinson’s disease according to cluster symptoms presentation (motor and non-motor symptoms) and using medications that act on multiple domains of PD symptoms.

Cite this article as:

Lauretani Fulvio, Saginario Antonio, Ceda Paolo Gian, Galuppo Laura, Ruffini Livia, Nardelli Anna and Maggio Marcello, Treatment of the Motor and Non-Motor Symptoms in Parkinson's Disease According to Cluster Symptoms Presentation, Current Drug Targets 2014; 15 (10) . https://dx.doi.org/10.2174/1389450115666140826104030