纳米材料在大脑中的诊断和治疗应用

Title:Diagnostic and Therapeutic Uses of Nanomaterials in the Brain

Volume: 21 Issue: 36

Author(s): Elisa Garbayo, Ander Estella-Hermoso de Mendoza and Maria J. Blanco-Prieto

Affiliation:

关键词: 阿尔茨海默病，脑肿瘤，诊断，工程纳米材料，纳米科技，纳米技术，帕金森病

摘要: Nanomedicine has recently emerged as an exciting tool able to improve the early diagnosis and treatment of a variety of intractable or age-related brain disorders. The most relevant properties of nanomaterials are that they can be engineered to cross the blood brain barrier, to target specific cells and molecules and to act as vehicles for drugs. Potentially beneficial properties of nanotherapeutics derived from its unique characteristics include improved efficacy, safety, sensitivity and personalization compared to conventional medicines. In this review, recent advances in available nanostructures and nanomaterials for brain applications will be described. Then, the latest applications of nanotechnology for the diagnosis and treatment of neurological disorders, in particular brain tumors and neurodegenerative diseases, will be reviewed. Recent investigations of the neurotoxicity of the nanomaterial both in vitro and in vivo will be summarized. Finally, the ongoing challenges that have to be meet if new nanomedical products are to be put on the market will be discussed and some future directions will be outlined.

Cite this article as:

Garbayo Elisa, Mendoza Estella-Hermoso de Ander and Blanco-Prieto J. Maria, Diagnostic and Therapeutic Uses of Nanomaterials in the Brain, Current Medicinal Chemistry 2014; 21 (36) . https://dx.doi.org/10.2174/0929867321666140815124246