摘要
最常见的神经紊乱,包括神经退化性疾病和神经疾病,在药物遗传学和个体化药物上已经得到了重视。在此,我们将重点研究被忽视的神经退化疾病、缺血性脑卒中以及重点介绍帕金森氏病和阿尔兹海默氏病这两种疾病的近期进展,这两者在潜在的治疗靶点上拥有相似又可区分的机制。在这篇论述的第一部分,我们将主要侧重在那些对每类疾病具有一定特异的神经衰弱(即蛋白酶通道、钙稳态、活性氧调控、DNA修复机制、神经调节、线粒体功能等)机理。在第二部分,我们将讨论全基因组技术的药物基因组学在在许多神经疾病上的应用,这些精神疾病包括精神分裂症、自闭症、小儿多动症以及强迫症。
关键词: 全基因组关联,神经退行性疾病,药物基因组学,神经疾病。
Current Molecular Medicine
Title:The Applications of Pharmacogenomics to Neurological Disorders
Volume: 14 Issue: 7
Author(s): C. Gilman, C. McSweeney and Y. Mao
Affiliation:
关键词: 全基因组关联,神经退行性疾病,药物基因组学,神经疾病。
摘要: The most common neurological disorders, including neurodegenerative diseases and psychiatric disorders, have received recent attention with regards to pharmacogenomics and personalized medicine. Here, we will focus on a neglected neurodegenerative disorder, cerebral ischemic stroke (CIS), and highlight recent advances in two disorders, Parkinson’s disease (PD) and Alzheimer’s diseases (AD), that possess both similar and distinct mechanisms in regards to potential therapeutic targets.
In the first part of this review, we will focus primarily on mechanisms that are somewhat specific to each disorder which are involved in neurodegeneration (i.e., protease pathways, calcium homeostasis, reactive oxygen species regulation, DNA repair mechanisms, neurogenesis regulation, mitochondrial function, etc.). In the second part of this review, we will discuss the applications of the genome-wide technology on pharmacogenomics of mental illnesses including schizophrenia (SCZ), autism spectrum disorders (ASD), attention deficit hyperactivity disorder (ADHD), and obsessive compulsive disorder (OCD).
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Cite this article as:
Gilman C., McSweeney C. and Mao Y., The Applications of Pharmacogenomics to Neurological Disorders, Current Molecular Medicine 2014; 14 (7) . https://dx.doi.org/10.2174/1566524014666140811115900
DOI https://dx.doi.org/10.2174/1566524014666140811115900 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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