Abstract
In recent times, the novel concept of generating hybrid molecules by pharmacophoric hybridisation approach is fast becoming an alternative to other existing strategies of drug development. These hybrids also known as ‘dual drugs’ or ‘double drugs’ are especially found to be effective in overcoming drug resistance problems. Towards this end, a lot of effort has been put for generating 4-aminoquinoline based hybrid molecules as next generation antimalarial drugs effective in malarial chemotherapy. This short review deals about the recent advances carried in the field of 4-aminoquinoline based molecular hybrids as potential antimalarial agents. It also presents a brief and simplified story on the development of 4-aminoquinolines as a mainstay in malarial research programmes.
Keywords: 4-Aminoquinoline, antimalarial, artemisinin, hybrid, pfDHFR.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:4-Aminoquinoline Based Molecular Hybrids as Antimalarials: An Overview
Volume: 14 Issue: 14
Author(s): Sunny Manohar, Mohit Tripathi and Diwan S. Rawat
Affiliation:
Keywords: 4-Aminoquinoline, antimalarial, artemisinin, hybrid, pfDHFR.
Abstract: In recent times, the novel concept of generating hybrid molecules by pharmacophoric hybridisation approach is fast becoming an alternative to other existing strategies of drug development. These hybrids also known as ‘dual drugs’ or ‘double drugs’ are especially found to be effective in overcoming drug resistance problems. Towards this end, a lot of effort has been put for generating 4-aminoquinoline based hybrid molecules as next generation antimalarial drugs effective in malarial chemotherapy. This short review deals about the recent advances carried in the field of 4-aminoquinoline based molecular hybrids as potential antimalarial agents. It also presents a brief and simplified story on the development of 4-aminoquinolines as a mainstay in malarial research programmes.
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Cite this article as:
Manohar Sunny, Tripathi Mohit and Rawat S. Diwan, 4-Aminoquinoline Based Molecular Hybrids as Antimalarials: An Overview, Current Topics in Medicinal Chemistry 2014; 14 (14) . https://dx.doi.org/10.2174/1568026614666140808125728
DOI https://dx.doi.org/10.2174/1568026614666140808125728 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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