摘要
阿尔茨海默病(AD)是导致成年人死亡的最主要的原因之一,目前为止它已经被视为危害公众健康的“紧急”疾病。目前用于AD的药物并非从病理上治疗,而仅从表症上,但仅仅是试着放慢或推迟病理的发展。而且,完全缺乏早期诊断,对AD病人的诊断只是用“大概”或“可能”的词汇。就此,我们旨在一一列举和突出治疗和诊断AD的最有前景的方法。根据这种观点,为了改善AD病人的检测(体内和体外)及治疗方式,我们研究和探讨了处在创新前沿的像聚合纳米粒子、微脂囊、纳米装配技术和树状聚合物等纳米载体。为了帮助区分价值及批判,本文对AD成像/检测和治疗方面的最杰出的纳米医学驱动方法进行了概括。此外报道和评论了关于AD诊断方面最有创新的策略之一,称作诊疗纳米医学的概述。
关键词: 阿尔茨海默病,AD影像,AD疗法,纳米载体,诊疗纳米医学
Current Medicinal Chemistry
Title:Nanotechnology and Alzheimer's Disease: What has been Done and What to Do'
Volume: 21 Issue: 36
Author(s): B. Ruozi, D. Belletti, F. Pederzoli, P. Veratti, F. Forni, M.A. Vandelli and G. Tosi
Affiliation:
关键词: 阿尔茨海默病,AD影像,AD疗法,纳米载体,诊疗纳米医学
摘要: Up to date, Alzheimer’s Disease (AD) is considered as an “urgency” for public health, since it represents one of the most dramatic causes of death in adults. The drugs currently used for AD are only symptomatic, thus not curing the pathology, but only trying to slow or delay the progression of the pathology. Moreover, there is a total lack of early identification, with only “probable’’ or ‘‘possible’’ diagnosis of AD patients. With this review, we aimed to individuate and to highlight the most promising approaches for AD therapy and diagnosis. In this view, at the cutting-edge of innovation, nanocarriers as polymeric nanoparticles, liposomes, nanoassembly and dendrimers, have been studied and investigated in order to ameliorate the detection (in vitro and in vivo) and/or the therapeutic options in AD. In this review, the most outstanding nanomedicine-driven approaches in AD imaging/detection and treatments are summarized in order to help in individuating values and criticisms. Moreover, an overview of one of the most innovative strategies in AD management, namely theranostic nanomedicine, is reported and commented.
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Cite this article as:
Ruozi B., Belletti D., Pederzoli F., Veratti P., Forni F., Vandelli M.A. and Tosi G., Nanotechnology and Alzheimer's Disease: What has been Done and What to Do', Current Medicinal Chemistry 2014; 21 (36) . https://dx.doi.org/10.2174/0929867321666140716100056
DOI https://dx.doi.org/10.2174/0929867321666140716100056 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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