Abstract
Tuberculosis vaccine research began with the search for a vaccine that might be better than, and thus could replace, the current Bacillus Calmette Guérin (BCG) vaccine. Over the last fifteen years or so, intense research effort has led to the identification of a number of novel tuberculosis (TB) vaccines which can be divided into 4 categories: genetically modified mycobacteria, protein, plasmid DNA and viral. However, it is increasingly believed that the current BCG vaccine will continue to be used as a childhood vaccine and that more effort should be directed to developing appropriate boosting vaccines. Mounting evidence suggests that recombinant genetic vaccines, particularly recombinant viral vaccines, are effective in boosting immune activation and protection by BCG vaccination. Since modified vaccinia virus Ankara (MVA)- and adenovirus-vectored TB vaccines have been most extensively studied, this review will focus on recent advances in the development and applications of these two viral TB vaccines.
Keywords: modified vaccinia virus Ankara, cmv promoters, gag gene, bcg vaccination, bovine models, genetically modified dendritic cell, immunopathology
Current Gene Therapy
Title: Recent Advances in the Development of Adenovirus- and Poxvirus- Vectored Tuberculosis Vaccines
Volume: 5 Issue: 5
Author(s): Zhou Xing, Michael Santosuosso, Sarah McCormick, Teng-Chih Yang, James Millar, Mary Hitt, Yonghong Wan, Jonathan Bramson and H. M. Vordermeier
Affiliation:
Keywords: modified vaccinia virus Ankara, cmv promoters, gag gene, bcg vaccination, bovine models, genetically modified dendritic cell, immunopathology
Abstract: Tuberculosis vaccine research began with the search for a vaccine that might be better than, and thus could replace, the current Bacillus Calmette Guérin (BCG) vaccine. Over the last fifteen years or so, intense research effort has led to the identification of a number of novel tuberculosis (TB) vaccines which can be divided into 4 categories: genetically modified mycobacteria, protein, plasmid DNA and viral. However, it is increasingly believed that the current BCG vaccine will continue to be used as a childhood vaccine and that more effort should be directed to developing appropriate boosting vaccines. Mounting evidence suggests that recombinant genetic vaccines, particularly recombinant viral vaccines, are effective in boosting immune activation and protection by BCG vaccination. Since modified vaccinia virus Ankara (MVA)- and adenovirus-vectored TB vaccines have been most extensively studied, this review will focus on recent advances in the development and applications of these two viral TB vaccines.
Export Options
About this article
Cite this article as:
Xing Zhou, Santosuosso Michael, McCormick Sarah, Yang Teng-Chih, Millar James, Hitt Mary, Wan Yonghong, Bramson Jonathan and Vordermeier M. H., Recent Advances in the Development of Adenovirus- and Poxvirus- Vectored Tuberculosis Vaccines, Current Gene Therapy 2005; 5 (5) . https://dx.doi.org/10.2174/156652305774329230
DOI https://dx.doi.org/10.2174/156652305774329230 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Phage Choice, Isolation, and Preparation for Phage Therapy
Current Pharmaceutical Biotechnology Microbial Cold Shock Proteins: Overview of their Function and Mechanism of Action
Protein & Peptide Letters The Hidden Face of Fetal Alcohol Spectrum Disorder
Current Women`s Health Reviews Antiretroviral Treatment as Prevention: Impact of the ‘Test and Treat’ Strategy on the Tuberculosis Epidemic
Current HIV Research Anti-Apoptotic Genes in the Survival of Monocytic Cells During Infection
Current Genomics Personalized Medicine, Bioethics and Social Responsibilities: Re-thinking the Pharmaceutical Industry to Remedy Inequities in Patient Care and International Health
Current Pharmacogenomics and Personalized Medicine An Update on Natural Products with Carbonic Anhydrase Inhibitory Activity
Current Pharmaceutical Design Rifampicin Induced Aggregation of Ovalbumin: Malicious Behaviour of Antibiotics
Protein & Peptide Letters Use of Etanercept in the Treatment of Psoriasis and Psoriatic Arthritis
Reviews on Recent Clinical Trials Anti-Oxidative Stress and Beyond: Multiple Functions of the Protein Glutathionylation
Protein & Peptide Letters Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of their Action
Current Topics in Medicinal Chemistry Emerging Therapies in Relapsing-Remitting Multiple Sclerosis
Reviews on Recent Clinical Trials Current Trends in Virtual High Throughput Screening Using Ligand-Based and Structure-Based Methods
Combinatorial Chemistry & High Throughput Screening Pulmonary Tuberculosis in Various Gene Knockout Mice With Special Emphasis on Roles of Cytokines and Transcription Factors
Current Respiratory Medicine Reviews Glycoconjugates of Quinolines: Application in Medicinal Chemistry
Mini-Reviews in Medicinal Chemistry Anti-Tumor Necrosis Factor-Alpha (TNF-α) Treatment Strategies in Crohns Disease
Recent Patents on Inflammation & Allergy Drug Discovery Preliminary Screening Indicates Promising Antimicrobial Properties of the Stem Bark Extracts of Macaranga rosea
Anti-Infective Agents Aminobisphosphonates as New Weapons for γ δ T Cell-Based Immunotherapy of Cancer
Current Medicinal Chemistry Allergic Aspergillosis and the Antigens of Aspergillus fumigatus
Current Protein & Peptide Science HPLC as a Tool in Medicinal Chemistry for the Monitoring of Tricyclic Antidepressants in Biofluids
Mini-Reviews in Medicinal Chemistry