摘要
自从硼替佐米被美国FDA批准作为第一个治疗多发性骨髓瘤的药物,各种各样的硼酸化合物已经研制成了酶抑制剂。本文对过去十年的蛋白酶体、丝氨酸蛋白酶、组蛋白去乙酰化酶和其它酶的硼酸类酶抑制剂的发展状况进行综述。
关键词: 硼酸,硼替佐米,酶抑制剂,组蛋白去乙酰化酶,蛋白酶体抑制剂,丝氨酸蛋白酶
Current Medicinal Chemistry
Title:Boronic Acid-based Enzyme Inhibitors: A Review of Recent Progress
Volume: 21 Issue: 28
Author(s): H. Fu, H. Fang, Jie Sun, H. Wang, A. Liu, J. Sun and Z. Wu
Affiliation:
关键词: 硼酸,硼替佐米,酶抑制剂,组蛋白去乙酰化酶,蛋白酶体抑制剂,丝氨酸蛋白酶
摘要: Since Bortezomib was approved by US FDA as the first drug to treat multiple myeloma, various boronic acid compounds have been developed as enzyme inhibitors. This paper reviewed the progress of boronic acid-based inhibitors against enzymes including proteasome, serine protease, HDACs and other enzymes in the past decade.
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Cite this article as:
Fu H., Fang H., Sun Jie, Wang H., Liu A., Sun J. and Wu Z., Boronic Acid-based Enzyme Inhibitors: A Review of Recent Progress, Current Medicinal Chemistry 2014; 21 (28) . https://dx.doi.org/10.2174/0929867321666140601200803
DOI https://dx.doi.org/10.2174/0929867321666140601200803 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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