Abstract
The synthesis of a new non-cross-linked polystyrene supported cyclosulfamide chiral auxiliary is described. Asymmetric aldol reactions using this auxiliary proceeded with good yields and excellent stereoselectivities, which were comparable with those observed by using non-supported cyclosulfamide chiral auxiliary. Furthermore, recovery and recycling of this polymer supported chiral auxiliary have been successfully achieved without appreciable reduction in the yield or stereoselectivity.
Keywords: Asymmetric aldol reactions, chiral auxiliary, cyclosulfamide, non-cross-linked polystyrene, supported.
Graphical Abstract
Current Organic Synthesis
Title:Non-Cross-Linked Polystyrene Supported Cyclosulfamide as a New Chiral Auxiliary for Asymmetric Aldol Reactions
Volume: 12 Issue: 1
Author(s): Taotao Lu, Cuifen Lu, Junqi Nie, Zuxing Chen and Guichun Yang
Affiliation:
Keywords: Asymmetric aldol reactions, chiral auxiliary, cyclosulfamide, non-cross-linked polystyrene, supported.
Abstract: The synthesis of a new non-cross-linked polystyrene supported cyclosulfamide chiral auxiliary is described. Asymmetric aldol reactions using this auxiliary proceeded with good yields and excellent stereoselectivities, which were comparable with those observed by using non-supported cyclosulfamide chiral auxiliary. Furthermore, recovery and recycling of this polymer supported chiral auxiliary have been successfully achieved without appreciable reduction in the yield or stereoselectivity.
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Cite this article as:
Lu Taotao, Lu Cuifen, Nie Junqi, Chen Zuxing and Yang Guichun, Non-Cross-Linked Polystyrene Supported Cyclosulfamide as a New Chiral Auxiliary for Asymmetric Aldol Reactions, Current Organic Synthesis 2015; 12 (1) . https://dx.doi.org/10.2174/1570179411666140530211735
DOI https://dx.doi.org/10.2174/1570179411666140530211735 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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