Abstract
This review deals with the applications of the Favorskii rearrangement in synthetic Organic Chemistry, paying especial attention to the literature appeared after 1980. The mentioned rearrangement plays a key role in many total synthesis due to the fact that important modifications in the structure of the substrate occur during the process. Skeletal rearrangements in acyclic systems, leading to highly branched carboxylic acids and its derivatives, as well as structural changes in cyclic substrates, which result in ring contraction processes, are described. Some examples of Favorskii rearrangements in biosynthetic pathways are also presented.
Keywords: skeletal rearrangement, Deprotonation, cyclopropanone, organic synthesis, Imine Derivatives, Favorskii-Like Processes, Homo-Favorskii Reactions
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Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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