Synthesis and Antifungal Activity of 1,2,3-thiadiazole Derivatives Containing 1,3,4-thiadiazole Moiety

Title:Synthesis and Antifungal Activity of 1,2,3-thiadiazole Derivatives Containing 1,3,4-thiadiazole Moiety

Volume: 11 Issue: 7

Author(s): Shui-Lin Yan, Ming-Yan Yang, Zhao-Hui Sun, Li-Jing Min, Cheng-Xia Tan, Jian-Quan Weng, Hong-Ke Wu and Xing-Hai Liu

Affiliation:

Keywords: 1, 2, 3-thiadiazole, 1, 3, 4-thiadiazole, Antifungal activity, Synthesis.

Abstract: A series of 4-methyl-N-(5-substituted-1, 3,4-thiadiazol-2-yl)-1,2,3-thiadiazole-5-carboxamide 6a~6j. The chemical structures were confirmed by ¹H NMR, FTIR, MS, and elemental analysis. All the compounds were investigated for antifungal activity. The antifungal activity results indicated that compound 6a exhibited good activities against C. arachidicola. It can be compared with the commercial drug. The compounds 6e, 6f, 6i, 6j exhibited moderate activity.

Cite this article as:

Yan Shui-Lin, Yang Ming-Yan, Sun Zhao-Hui, Min Li-Jing, Tan Cheng-Xia, Weng Jian-Quan, Wu Hong-Ke and Liu Xing-Hai, Synthesis and Antifungal Activity of 1,2,3-thiadiazole Derivatives Containing 1,3,4-thiadiazole Moiety, Letters in Drug Design & Discovery 2014; 11 (7) . https://dx.doi.org/10.2174/1570180811666140423222141