Abstract
IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and remains an important cause of end-stage renal failure. However, the basic molecular mechanism(s) underlying abnormal IgA synthesis, selective mesangial deposition with ensuing mesangial cell proliferation and extracellular matrix expansion remains poorly understood. Notably, the severity of tubulointerstitial lesions better predicts the renal progression than the degree of glomerular lesions. The task of elucidating the molecular basis of IgAN is made especially challenging by the fact that both environmental and genetic components likely contribute to the development and progression of IgAN. This review will summarize the earlier works on the structure of the IgA molecule, mechanisms of mesangial IgA deposition and pathophysiologic effects of IgA on mesangial cells following mesangial deposition. Recently, a series of important advances in the area of communication between the glomerular mesangium and renal tubular cells have emerged. These novel findings regarding the molecular pathogenesis of IgAN will be helpful in designing future directions for therapy.
Keywords: Iga nephropathy, Iga, mesangial inflammation, tubulointerstitial injury, electrostatic charge, growth factors, renin-angiotensin system, angiotensin II receptors
Current Molecular Medicine
Title: Molecular Basis of IgA Nephropathy
Volume: 5 Issue: 5
Author(s): Andrew S.H. Lai and Kar Neng Lai
Affiliation:
Keywords: Iga nephropathy, Iga, mesangial inflammation, tubulointerstitial injury, electrostatic charge, growth factors, renin-angiotensin system, angiotensin II receptors
Abstract: IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and remains an important cause of end-stage renal failure. However, the basic molecular mechanism(s) underlying abnormal IgA synthesis, selective mesangial deposition with ensuing mesangial cell proliferation and extracellular matrix expansion remains poorly understood. Notably, the severity of tubulointerstitial lesions better predicts the renal progression than the degree of glomerular lesions. The task of elucidating the molecular basis of IgAN is made especially challenging by the fact that both environmental and genetic components likely contribute to the development and progression of IgAN. This review will summarize the earlier works on the structure of the IgA molecule, mechanisms of mesangial IgA deposition and pathophysiologic effects of IgA on mesangial cells following mesangial deposition. Recently, a series of important advances in the area of communication between the glomerular mesangium and renal tubular cells have emerged. These novel findings regarding the molecular pathogenesis of IgAN will be helpful in designing future directions for therapy.
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Cite this article as:
Lai S.H. Andrew and Lai Neng Kar, Molecular Basis of IgA Nephropathy, Current Molecular Medicine 2005; 5 (5) . https://dx.doi.org/10.2174/1566524054553450
DOI https://dx.doi.org/10.2174/1566524054553450 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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