Imidazol-1-yl-acetic Acid as a Green Simple Bifunctional Organocatalyst for the Regioselective Conversion of Epoxides to 1,2-azido Alcohols and β-hydroxythiocyanates

Title:Imidazol-1-yl-acetic Acid as a Green Simple Bifunctional Organocatalyst for the Regioselective Conversion of Epoxides to 1,2-azido Alcohols and β-hydroxythiocyanates

Volume: 1 Issue: 1

Author(s): Simin Nazari, Nasir Iravani, Amanollah Zarei Ahmady, Masoumeh Vafaee-nezhad and Mosadegh Keshavarz

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Keywords: Imidazol-1-yl-acetic acid, epoxide, ring opening, bifunctional organocatalyst, sodium azide, sodium thiocyanate. green chemistry, nucleophile, electrophile, regioselective.

Abstract: Imidazol-1-yl-acetic acid is introduced as a new, efficient and recyclable green bifunctional organocatalyst for the synthesis of β-hydroxythiocyanate and 1,2-azido alcohols under mild conditions. This catalyst can be recovered by simple filtration and recycled up to 8 consecutive runs without losing any of its efficiency. Various advantages associated with this protocol include simple workup procedure, short reaction times, high product yields, greater regioselectivity.

Cite this article as:

Nazari Simin, Iravani Nasir, Ahmady Zarei Amanollah, Vafaee-nezhad Masoumeh and Keshavarz Mosadegh, Imidazol-1-yl-acetic Acid as a Green Simple Bifunctional Organocatalyst for the Regioselective Conversion of Epoxides to 1,2-azido Alcohols and β-hydroxythiocyanates, Current Organocatalysis 2014; 1 (1) . https://dx.doi.org/10.2174/2213337201666140303235842